Click chemistry:: Copper clusters catalyse the cycloaddition of azides with terminal alkynes

被引：270

作者：

Pachón, LD ^{[1
]}

van Maarseveen, JH ^{[1
]}

Rothenberg, G ^{[1
]}

机构：

[1] Univ Amsterdam, Vant Hoff Inst Mol Sci, NL-1018 WV Amsterdam, Netherlands

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2005年 / 347卷 / 06期

关键词：

azides; cycloaddition; kinetics; mechanism; nanoclusters; triple bonds;

D O I：

10.1002/adsc.200404383

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Air-stable copper nanoclusters are good catalysts in the Cu(I)-catalysed "click" cycloaddition of azides with terminal alkynes to give 1,4-disubstituted 1,2,3-triazoles. No additional base or reducing agent is required. The reaction kinetics using various copper catalyst types and the function of copper particles in this system are studied and discussed.

引用

页码：811 / 815

页数：5

共 33 条

[31] Bioconjugation by copper(I)-catalyzed azide-alkyne [3+2] cycloaddition
Wang, Q
Chan, TR
Hilgraf, R
Fokin, VV
Sharpless, KB
Finn, MG
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2003, 125 (11) : 3192 - 3193
[32] Regioselective synthesis of 1,2,3-triazole derivatives via 1,3-dipolar cycloaddition reactions in water
Wang, ZX
Qin, HL
[J]. CHEMICAL COMMUNICATIONS, 2003, (19) : 2450 - 2451
[33] Efficiency and fidelity in a click-chemistry route to triazole dendrimers by the copper(I)-catalyzed ligation of azides and alkynes
Wu, P
Feldman, AK
Nugent, AK
Hawker, CJ
Scheel, A
Voit, B
Pyun, J
Fréchet, JMJ
Sharpless, KB
Fokin, VV
[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2004, 43 (30) : 3928 - 3932

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