Mitochondria in innate immune responses

被引：1046

作者：

West, A. Phillip ^{[2
]}

Shadel, Gerald S. ^{[2
,3
]}

Ghosh, Sankar ^{[1
]}

机构：

[1] Columbia Univ, Dept Microbiol & Immunol, Coll Phys & Surg, New York, NY 10032 USA

[2] Yale Univ, Sch Med, Dept Pathol, New Haven, CT 06520 USA

[3] Yale Univ, Sch Med, Dept Genet, New Haven, CT 06520 USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2011年 / 11卷 / 06期

基金：

美国国家卫生研究院;

关键词：

NF-KAPPA-B; INTERFERON REGULATORY FACTOR-3; NLRP3 INFLAMMASOME ACTIVATION; ANTIVIRAL SIGNALING PROTEIN; RIG-I; UNCOUPLING PROTEIN-2; ADAPTER PROTEIN; ENDOPLASMIC-RETICULUM; CRYSTAL-STRUCTURE; NECROTIC CELLS;

D O I：

10.1038/nri2975

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The innate immune system has a key role in the mammalian immune response. Recent research has demonstrated that mitochondria participate in a broad range of innate immune pathways, functioning as signalling platforms and contributing to effector responses. In addition to regulating antiviral signalling, mounting evidence suggests that mitochondria facilitate antibacterial immunity by generating reactive oxygen species and contribute to innate immune activation following cellular damage and stress. Therefore, in addition to their well-appreciated roles in cellular metabolism and programmed cell death, mitochondria appear to function as centrally positioned hubs in the innate immune system. Here, we review the emerging knowledge about the roles of mitochondria in innate immunity.

引用

页码：389 / 402

页数：14

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