The role of microRNA-26a in human cancer progression and clinical application

被引：54

作者：

Chen, Jing ^{[1
]}

Zhang, Kai ^{[1
]}

Xu, Yuejuan ^{[2
]}

Gao, Yanping ^{[1
]}

Li, Chen ^{[1
]}

Wang, Rui ^{[1
]}

Chen, Longbang ^{[1
]}

机构：

[1] Nanjing Univ, Sch Med, Dept Med Oncol, Jinling Hosp, 305 Zhong Shan Rd East, Nanjing 210008, Jiangsu, Peoples R China

[2] Jiangsu Canc Hosp, Dept Med Oncol, Nanjing, Jiangsu, Peoples R China

来源：

TUMOR BIOLOGY | 2016年 / 37卷 / 06期

基金：

中国国家自然科学基金;

关键词：

MicroRNA-26a; Cancer progression; Pathological functions; Clinical application; HUMAN HEPATOCELLULAR-CARCINOMA; EPITHELIAL-MESENCHYMAL TRANSITION; INHIBITS CELL-PROLIFERATION; SUPPRESSES TUMOR-GROWTH; RNA-INTERFERENCE; DOWN-REGULATION; NASOPHARYNGEAL CARCINOMA; EXPRESSION SIGNATURE; REGULATE EXPRESSION; ANDROGEN RECEPTOR;

D O I：

10.1007/s13277-016-5017-y

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

MicroRNAs, a class of endogenous, small (18-25 nucleotides) noncoding RNAs, regulate gene expression by directly binding to the 3'-untranslated regions of target messenger RNAs. Evidence has shown that alteration of microRNAs is involved in cancer initial and progression. MicroRNA-26a is commonly dysregulated in diverse cancers and is involved in various biological processes, including proliferation, migration, invasion, angiogenesis, and metabolism by targeting multiple mRNAs. This review summarizes current research on the physiology and pathological functions of miR-26a and its applications for clinical therapy.

引用

收藏

页码：7095 / 7108

页数：14

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