New indolopyridoquinazoline, benzo[c]phenanthridines and cytotoxic constituents from Zanthoxylum integrifoliolum

被引：68

作者：

Chen, JJ ^{[1
]}

Fang, HY

Duh, CY

Chen, IS

机构：

[1] Tajen Inst Technol, Dept Pharm, Grad Inst Pharmaceut Technol, Pingtung 907, Taiwan

[2] Natl Sun Yat Sen Univ, Inst Marine Resources, Kaohsiung 80424, Taiwan

[3] Kaohsiung Med Univ, Sch Pharm, Kaohsiung, Taiwan

来源：

PLANTA MEDICA | 2005年 / 71卷 / 05期

关键词：

Zanthoxylum integrifoliolum; Rutaceae; root bark; 7,8-dehydro-1-methoxyrutaecarpine; isodecarine; 8-demethyloxychelerythrine; cytotoxicity;

D O I：

10.1055/s-2005-864144

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Three new alkaloids, 7,8-dehydro-1-methoxyrutaecarpine, isodecarine, and 8-demethyloxychelerythrine, together with sixteen known compounds, norchelerythrine, oxychelerythrine, decarine, dihydrochetythrinylacetaldehyde, 6-acetonyldihydro-chelerythrine, rutaecarpine, 1-hydroxyrutaecarpine, gamma-fagarine, skimmianine, (-)-matairesinol, (-)-isoarctigenin, (+)-epipinoresinol, d-sesamin, lupeol, canthin-6-one, and arnottianamide have been isolated from the root bark of Zanthoxyluin integrifoliolum. The structures of these new compounds were determined through spectral analyses. Among the isolates, 7,8-dehydro-1 -methoxyrutaecarpine, norchelerythrine, oxychelerythrine, dihydrocherythrinylacetaldehyde, 6-acetonyldihydrochelerythrine, 1-hydroxyrutaecarpine, gamma-fagarine, skimmianine, (-)-matairesinol, and canthin-6-one exhibited cytotoxicities (ED50 values < 4 yg/mL) against P-388 or HT-29 cell lines in vitro.

引用

页码：470 / 475

页数：6

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