Mollamides B and C, cyclic hexapeptides from the Indonesian tunicate Didemnum molle

被引：76

作者：

Donia, Marwa S. ^{[1
]}

Wang, Bin ^{[1
]}

Dunbar, Daniel C. ^{[1
]}

Desai, Prashant V. ^{[2
]}

Patny, Akshay ^{[2
]}

Avery, Mitchell ^{[2
]}

Hamann, Mark T. ^{[1
]}

机构：

[1] Univ Mississippi, Sch Pharm, Dept Pharmacognosy, University, MS 38677 USA

[2] Univ Mississippi, Sch Pharm, Dept Med Chem, University, MS 38677 USA

来源：

JOURNAL OF NATURAL PRODUCTS | 2008年 / 71卷 / 06期

关键词：

D O I：

10.1021/np700718p

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

Two new cyclic hexapeptides, mollamides B (1) and C (2), were isolated from the Indonesian tunicate Didemnum molle along with the known peptide keenamide A (3). The structures were established using ID and 2D NMR experiments. The relative configuration of mollamide B at the thiazoline moiety was determined using molecular modeling coupled with NMR-derived restraints. Their absolute configuration was determined using Marfey's method. The new peptides have been evaluated for their antimicrobial., antimalarial, anticancer, anti-HIV-1, anti-Mtb, and anti-inflammatory activities. Keenamide A and mollamide B show cytotoxicity against several cancer cell lines.

引用

页码：941 / 945

页数：5

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