Alzheimer's disease

被引：2476

作者：

Lane, C. A. ^{[1
]}

Hardy, J. ^{[2
]}

Schott, J. M. ^{[1
]}

机构：

[1] UCL Inst Neurol, Dementia Res Ctr, London, England

[2] UCL Inst Neurol, Reta Lila Weston Res Labs, Dept Mol Neurosci, London, England

来源：

EUROPEAN JOURNAL OF NEUROLOGY | 2018年 / 25卷 / 01期

基金：

英国工程与自然科学研究理事会; 欧盟地平线“2020”; “创新英国”项目;

关键词：

Alzheimer's disease; epidemiology; genetics; pathogenesis; pathology; treatment; MILD COGNITIVE IMPAIRMENT; NATIONAL INSTITUTE; ASSOCIATION WORKGROUPS; DIAGNOSTIC GUIDELINES; AMYLOID HYPOTHESIS; NEUROPATHOLOGIC ASSESSMENT; MICROGLIAL ACTIVATION; BLOOD BIOMARKERS; NATURAL-HISTORY; BETA PLAQUES;

D O I：

10.1111/ene.13439

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

100204 [神经病学];

摘要：

Alzheimer's disease, the commonest cause of dementia, is a growing global health concern with huge implications for individuals and society. In this review, current understanding of the epidemiology, genetics, pathology and pathogenesis of Alzheimer's disease is outlined, before its clinical presentation and current treatment strategies are discussed. Finally, the review discusses how our enhanced understanding of Alzheimer pathogenesis, including the recognition of a protracted preclinical phase, is informing new therapeutic strategies with the aim of moving from treatment to prevention.

引用

页码：59 / 70

页数：12

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