Characterization of a Tal/SCL-like transcription factor in the pacific oyster Crassostrea gigas

被引：19

作者：

Barreau-Roumiguière, C ^{[1
]}

Montagnani, C ^{[1
]}

Escoubas, JM ^{[1
]}

机构：

[1] Univ Montpellier 2, Lab Def & Resistance Chez Invertebres Marins, UMR 5098, IFREMER CNRS UMII, F-34095 Montpellier, France

来源：

DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY | 2003年 / 27卷 / 09期

关键词：

transcription factor; hemocyte; oyster; Crassostrea gigas; cell proliferation; mollusk immunity; hematopoiesis;

D O I：

10.1016/S0145-305X(03)00075-2

中图分类号：

S9 [水产、渔业];

学科分类号：

0908 ;

摘要：

We have cloned and characterized a cDNA encoding Cg-tal in the Pacific oyster Crassostrea gigas. The isolated cDNA encodes a 219 amino acids protein that contains the basic helix-loop-helix (bHLH) domain homologous to that of vertebrate and invertebrate Tal1/SCL. Phylogenetic analyses sustained that Cg-Tal belongs to this family of bHLH transcription factors. Northern blot analysis of Cg-tal mRNA expression in adult oyster tissues indicated that Cg-tal was specifically expressed in hemocytes, in a constitutive manner. In vertebrates, activation of Tal1/SCL expression is essential for the initiation of hematopoiesis and the formation of hematopoietic stem cells. Considering Tat1/SCL function in vertebrates, Cg-Tal is likely to constitute a promising tool for studying hematopoiesis in oyster. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：793 / 800

页数：8

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