Solutions for library encoding to create collections of discrete compounds

被引:30
作者
Affleck, RL [1 ]
机构
[1] Discovery Partners Int, San Diego, CA 92121 USA
关键词
D O I
10.1016/S1367-5931(00)00200-3
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The ability to design, produce, analyze, and manage high quality combinatorial libraries depends on the encoding strategy applied. Several recent advances in encoding technology have extended the range of library design parameters. Enhancements of established techniques have made them more robust and versatile, while additional new and creative encoding concepts have been introduced. With better options now available, combinatorial chemists can more easily select an encoding technique to match resources, library design, and compound management criteria.
引用
收藏
页码:257 / 263
页数:7
相关论文
共 41 条
  • [21] Lane SJ, 2000, RAPID COMMUN MASS SP, V14, P782, DOI 10.1002/(SICI)1097-0231(20000515)14:9<782::AID-RCM944>3.0.CO
  • [22] 2-D
  • [23] Pairwise use of complexity-generating reactions in diversity-oriented organic synthesis
    Lee, DS
    Sello, JK
    Schreiber, SL
    [J]. ORGANIC LETTERS, 2000, 2 (05) : 709 - 712
  • [24] Kinetic study of organic reactions on polystyrene grafted MicroTubes
    Li, WB
    Czarnik, AW
    Lillig, J
    Xiao, XY
    [J]. JOURNAL OF COMBINATORIAL CHEMISTRY, 2000, 2 (03): : 224 - 227
  • [25] Solid-phase oligonucleotide synthesis and flow cytometric analysis with microspheres encoded with covalently attached fluorophores
    Nanthakumar, A
    Pon, RT
    Mazumder, A
    Yu, SY
    Watson, A
    [J]. BIOCONJUGATE CHEMISTRY, 2000, 11 (02) : 282 - 288
  • [26] Regiochemical tagging: A new tool for structural characterization of isomeric components in combinatorial mixtures
    Nazarpack-Kandlousy, N
    Chernushevich, IV
    Meng, LJ
    Yang, Y
    Eliseev, AV
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2000, 122 (14) : 3358 - 3366
  • [27] Natural product-like combinatorial libraries based on privileged structures. 2. Construction of a 10 000-membered benzopyran library by directed split-and-pool chemistry using NanoKans and optical encoding
    Nicolaou, KC
    Pfefferkorn, JA
    Mitchell, HJ
    Roecker, AJ
    Barluenga, S
    Cao, GQ
    Affleck, RL
    Lillig, JE
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2000, 122 (41) : 9954 - 9967
  • [28] COMPLEX SYNTHETIC CHEMICAL LIBRARIES INDEXED WITH MOLECULAR TAGS
    OHLMEYER, MHJ
    SWANSON, RN
    DILLARD, LW
    READER, JC
    ASOULINE, G
    KOBAYASHI, R
    WIGLER, M
    STILL, WC
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (23) : 10922 - 10926
  • [29] Discovery of selective metal-binding peptoids using 19F encoded combinatorial libraries
    Pirrung, MC
    Park, K
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2000, 10 (18) : 2115 - 2118
  • [30] Spatially addressed synthesis of amino- and amino-oxy-substituted 1,3,5-triazine arrays on polymeric membranes
    Scharn, D
    Wenschuh, H
    Reineke, U
    Schneider-Mergener, J
    Germeroth, L
    [J]. JOURNAL OF COMBINATORIAL CHEMISTRY, 2000, 2 (04): : 361 - 369