Levodopa increases memory encoding and dopamine release in the striatum in the elderly

被引:62
作者
Floel, A. [1 ,2 ,3 ]
Garraux, G. [1 ]
Xu, B. [1 ]
Breitenstein, C. [2 ,3 ]
Knecht, S. [2 ,3 ]
Herscovitch, P. [4 ]
Cohen, L. G. [1 ]
机构
[1] NINDS, Human Cort Physiol Sect, NIH, Bethesda, MD 20892 USA
[2] Univ Munster, Dept Neurol, D-48129 Munster, Germany
[3] Univ Munster, IMF Munster, Munster, Germany
[4] NIH, Positron Emiss Tomog Dept, Ctr Clin, Bethesda, MD 20892 USA
关键词
aging; motor; memory formation; positron emission tomography; neuropharmacology; neurotransmitter; neurorehabilitation;
D O I
10.1016/j.neurobiolaging.2006.10.009
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
Normal aging is associated with a decrease in dopaminergic function and a reduced ability to form new motor memories with training. This study examined the link between both phenomena. We hypothesized that levodopa would (a) ameliorate aging-dependent deficits in motor memory formation, and (b) increase dopamine availability at the dopamine type 2-like (D2) receptor during training in task-relevant brain structures. The effects of training plus levodopa (100 mg, plus 25 mg carbidopa) on motor memory formation and striatal dopamine availability were measured with [C-11]raclopride (RAC) positron emission tomography (PET). We found that levodopa did not alter RAC-binding potential at rest but it enhanced training effects on motor memory formation as well as dopamine release in the dorsal caudate nucleus. Motor memory formation during training correlated with the increase of dopamine release in the caudate nucleus. These results demonstrate that levodopa may ameliorate dopamine deficiencies in the elderly by replenishing dopaminergic presynaptic stores, actively engaged in phasic dopamine release during motor training. (C) 2006 Elsevier Inc. All rights reserved.
引用
收藏
页码:267 / 279
页数:13
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