Indium-mediated addition of 4-bromocrotonic acid to aldehydes and ketones -: A simple, high yielding route to α-allyl-β-hydroxy carboxylic acids

被引：5

作者：

Bowyer, MC

Gordon, CM

Leitch, SK

McCluskey, A ^{[1
]}

Ritchie, C

机构：

[1] Univ Newcastle, Sch Environm & Life Sci, Callaghan, NSW 2308, Australia

[2] Univ Newcastle, Sch Appl Sci, Ourimbah, NSW 2258, Australia

[3] Univ Strathclyde, Dept Pure & Appl Chem, Glasgow G1 1XL, Lanark, Scotland

来源：

AUSTRALIAN JOURNAL OF CHEMISTRY | 2004年 / 57卷 / 02期

关键词：

D O I：

10.1071/CH03212

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We report a simple procedure for the indium-mediated addition of 4-bromocrotonic acid to a variety of aldehydes and ketones. In all instances the reaction proceeds exclusively with alpha-addition and typically in moderate to good yields (42-100%). The effect of solvent is minimal allowing a wide choice of conditions ( methanol, ethanol, ethanol/water, water, tetrahydrofuran, and the ionic liquid [bmIm][BF4]).

引用

页码：135 / 137

页数：3

共 19 条

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Curran DP, 1998, MED CHEM RES, V8, P261

[2]

GORDON C, UNPUB

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