A convenient route to both enantiomers of endo-2-benzonorbornenol via lipase catalysed resolution of the racemic mixture

被引：7

作者：

Fernández, F

Garcia-Mera, X ^{[1
]}

Rodríguez-Borges, JE

机构：

[1] Univ Santiago de Compostela, Fac Farm, Dept Quim Organ, E-15706 Santiago, Spain

[2] Fac Ciencias, Dept Quim, P-4169007 Porto, Portugal

来源：

TETRAHEDRON-ASYMMETRY | 2001年 / 12卷 / 03期

关键词：

D O I：

10.1016/S0957-4166(01)00079-9

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Resolution of racemic endo-benzonorbornenol (+/-)-4 was performed using Candida antaretica lipase (Novozym" 435) in benzene (50 degreesC;50 hours) with vinyl acetate as the acyl donor to afford (-)-endo-2-benzonorbornenol (-)-6 and their corresponding (+)-endo-2-benzonorbornenyl acetate (+)-5 in high e.e.s of up to 99'% and workable yields of up to 45-46%. (C) 2001 Elsevier Science Ltd. All rights: reserved.

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页码：365 / 368

页数：4

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