A Lipase-Responsive Vehicle Using Amphipathic Polymer Synthesized with the Lipase as Catalyst

被引:35
作者
Ge, Jun [1 ]
Lu, Diannan [1 ]
Yang, Cheng [1 ]
Liu, Zheng [1 ]
机构
[1] Tsinghua Univ, Dept Chem Engn, State Key Lab Chem Engn, Beijing 100084, Peoples R China
基金
中国国家自然科学基金;
关键词
biomaterials; enzymes; nanoparticles; stimuli-sensitive polymers; CANDIDA-RUGOSA LIPASE; MESOPOROUS SILICA; BLOCK-COPOLYMERS; ORGANIC-SOLVENTS; ENZYME-ACTIVITY; RELEASE; NANOPARTICLES; SYSTEM; TEMPERATURE; SURFACTANTS;
D O I
10.1002/marc.201000746
中图分类号
O63 [高分子化学(高聚物)];
学科分类号
070305 ; 080501 ; 081704 ;
摘要
We describe an enzyme-responsive polymeric vehicle, which is of great interest in controlled drug delivery, biosensing, and other related areas. The polymer synthesized using lipase as catalyst in DMSO has a favorable molecular structure that is quickly hydrolyzed by lipase in aqueous phase, and allows a fast release of encapsulated molecules.
引用
收藏
页码:546 / 550
页数:5
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