In vitro activity of tigecycline against multidrug-resistant Acinetobacter baumannii and selection of tigecycline-amikacin synergy

被引：35

作者：

Moland, Ellen S.

Craft, David W. ^{[2
]}

Hong, Seong-geun

Kim, Soo-young

Hachmeister, Lucas

Sayed, Shimon D.

Thomson, Kenneth S. ^{[1
]}

机构：

[1] Creighton Univ, Sch Med, Dept Med Microbiol & Immunol, Omaha, NE 68178 USA

[2] Walter Reed Army Med Ctr, Washington, DC 20307 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2008年 / 52卷 / 08期

关键词：

D O I：

10.1128/AAC.01581-07

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Polymyxin B, minocycline, and tigecycline were the most potent of 10 antibiotics against 170 isolates of multidrug-resistant Acinetobacter baumannii. In time-kill studies, the exposure of a highly tigecycline-resistant isolate to tigecycline resulted in enhanced susceptibility to amikacin and synergistic bactericidal activities of the two drugs.

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收藏

页码：2940 / 2942

页数：3

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