Motion correction algorithms may create spurious brain activations in the absence of subject motion

被引:245
作者
Freire, L [1 ]
Mangin, JF
机构
[1] Serv Hosp Frederic Joliot, CEA, F-91401 Orsay, France
[2] Inst Med Nucl, FML, P-1649028 Lisbon, Portugal
关键词
fMRI; motion correction; artifact; spurious activation; robust registration;
D O I
10.1006/nimg.2001.0869
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
This paper describes several experiments that prove that standard motion correction methods may induce spurious activations in some motion-free fMRI studies. This artifact stems from the fact that activated areas behave like biasing outliers for the difference of square-based measures usually driving such registration methods. This effect is demonstrated first using a motion-free simulated time series including artificial activation-like signal changes. Several additional simulations explore the influence of activation amplitude and extent. The effect is finally highlighted on an actual time series obtained from a 3-T magnet. All the experiments are performed using four different realignment methods, which allows us to show that the problem may be overcome by methods based on a robust similarity measure like mutual information. (C) 2001 Academic Press.
引用
收藏
页码:709 / 722
页数:14
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