Anti-asthmatic effects of Angelica dahurica against ovalbumin-induced airway inflammation via upregulation of heme oxygenase-1

被引：72

作者：

Lee, Mee-Young ^{[1
]}

Seo, Chang-Seob ^{[1
]}

Lee, Jin-Ah ^{[1
]}

Lee, Nam-Hun ^{[1
]}

Kim, Jung-Hoon ^{[1
]}

Ha, Heykyung ^{[1
]}

Zheng, Ming-Shan ^{[2
]}

Son, Jong-Keun ^{[2
]}

Shin, Hyeun-Kyoo ^{[1
]}

机构：

[1] Korea Inst Oriental Med, Herbal Med EBM Res Ctr, Taejon 305811, South Korea

[2] Yeungnam Univ, Coll Pharm, Gyongsan 712749, Cyeongbuk, South Korea

来源：

FOOD AND CHEMICAL TOXICOLOGY | 2011年 / 49卷 / 04期

关键词：

Angelica dahurica Bentham et Hooker; Asthma; Eosinophilia; Cytokine; Heme oxygenase-1; NECROSIS-FACTOR-ALPHA; MURINE MODEL; LUNG INFLAMMATION; OXIDATIVE STRESS; CARBON-MONOXIDE; NADPH OXIDASE; ASTHMA MODEL; MAST-CELLS; T-CELLS; EXPRESSION;

D O I：

10.1016/j.fct.2010.12.004

中图分类号：

TS2 [食品工业];

学科分类号：

100403 [营养与食品卫生学];

摘要：

Asthma is a chronic immune inflammatory disease characterized by variable airflow obstruction. The present study was undertaken to assess the effects of an Angelica dahurica Bentham et Hooker ethanolic extract (AD) on airway inflammation in an ovalbumin (OVA)-induced airway inflammation model. Mice that received AD displayed significantly lower airway eosinophilia, cytokine levels, including interleukin (IL)-4, IL-5, and tumor necrosis factor (TNF)-alpha levels, mucus production and immunoglobulin (Ig)E, compared with OVA-induced mice. In our experiments, AD treatment reduced airway inflammation and suppressed oxidative stress in the OVA-induced asthma model, partly via induction of heme oxygenase (HO)-1. The effects of AD on OVA-induced HO-1 induction were partially reversed by the HO-1 inhibitor, tin protoporphyrin (SnPP). Our results clearly indicate that AD is a suppressor of airway allergic inflammation, and may thus be effectively used as an anti-inflammatory drug in the treatment of asthma. Crown Copyright (C) 2010 Published by Elsevier Ltd. All rights reserved.

引用

页码：829 / 837

页数：9

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