Structural features of trinucleotide repeats associated with DNA expansion

被引：38

作者：

Kovtun, IV

Goellner, G

McMurray, CT

机构：

[1] Mayo Clin & Mayo Fdn, Dept Mol Pharmacol & Expt Therapeut, Rochester, MN 55905 USA

[2] Mayo Clin & Mayo Fdn, Mol Neurosci Program, Rochester, MN 55905 USA

来源：

BIOCHEMISTRY AND CELL BIOLOGY | 2001年 / 79卷 / 03期

关键词：

expansion; hairpin; trinucleotide repeat; polymerase slippage; recombination; repair;

D O I：

10.1139/bcb-79-3-325

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The mechanism of DNA expansion is not well understood. Recent evidence from genetic, in vivo, and in vitro studies has suggested a link between the formation of alternative DNA secondary structures by trinucleotide repeat tracts and their propensity to undergo expansion. This review will focus on structural features and the mechanism of expansion relevant to human disease.

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收藏

页码：325 / 336

页数：12

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