Sensing of RNA Viruses: a Review of Innate Immune Receptors Involved in Recognizing RNA Virus Invasion

被引：456

作者：

Jensen, Soren ^{[1
]}

Thomsen, Allan Randrup ^{[1
]}

机构：

[1] Univ Copenhagen, Inst Int Hlth Immunol & Microbiol, Copenhagen, Denmark

来源：

JOURNAL OF VIROLOGY | 2012年 / 86卷 / 06期

关键词：

TOLL-LIKE RECEPTOR; DOUBLE-STRANDED-RNA; PLASMACYTOID DENDRITIC CELLS; NF-KAPPA-B; WEST-NILE-VIRUS; LYMPHOCYTIC-CHORIOMENINGITIS-VIRUS; PATTERN-RECOGNITION RECEPTORS; INTERFERON ANTIVIRAL RESPONSE; RESPIRATORY SYNCYTIAL VIRUS; IRF3 TRANSCRIPTION FACTOR;

D O I：

10.1128/JVI.05738-11

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Our knowledge regarding the contribution of the innate immune system in recognizing and subsequently initiating a host response to an invasion of RNA virus has been rapidly growing over the last decade. Descriptions of the receptors involved and the molecular mechanisms they employ to sense viral pathogen-associated molecular patterns have emerged in great detail. This review presents an overview of our current knowledge regarding the receptors used to detect RNA virus invasion, the molecular structures these receptors sense, and the involved downstream signaling pathways.

引用

页码：2900 / 2910

页数：11

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