Copper-Catalyzed Activation of Disulfides as a Key Step in the Synthesis of Benzothiazole Moieties

被引：41

作者：

Hyvl, Jakub ^{[1
]}

Srogl, Jiri ^{[1
]}

机构：

[1] Acad Sci Czech Republ, Inst Organ Chem & Biochem, CR-16610 Prague 6, Czech Republic

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2010年 / 2010卷 / 15期

关键词：

Oxidation; Copper; C-H activation; Disulfides; Imines; N; S heterocycles; Benzothiazole synthesis; BIS(MU-THIOLATO)DICOPPER(II) COMPLEX; CYCLIZATION; CLEAVAGE; POTENT;

D O I：

10.1002/ejoc.201000174

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A convenient synthesis of substituted benzothiazoles has been accomplished by way of a copper catalyzed reaction of aromatic disulfide amines and aldehydes. The process, which involves copper catalyzed activation of disulfide functionality, proceeds in a tandem fashion via C-H bond activation, followed by aerobic oxidation of a resulting dihydrobenzothiazole intermediate. The scope and limitations of the reaction are demonstrated on a variety of substrates.

引用

页码：2849 / 2851

页数：3

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