Foot in mouth: do focal adhesions disassemble by endocytosis?

被引:13
作者
Burridge, K [1 ]
机构
[1] Univ N Carolina, Dept Cell & Dev Biol, Chapel Hill, NC 27599 USA
[2] Univ N Carolina, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27599 USA
关键词
D O I
10.1038/ncb0505-545
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
How cells disassemble their focal adhesions is not well understood. Now, Ezratty et al. have shown that the GTPase dynamin acts after microtubule targeting of focal adhesions to trigger their disassembly. One intriguing possibility is that dynamin might drive disassembly through endocytosis.
引用
收藏
页码:545 / 547
页数:4
相关论文
共 15 条
[1]   RAC1 regulates adherens junctions through endocytosis of E-cadherin [J].
Akhtar, N ;
Hotchin, NA .
MOLECULAR BIOLOGY OF THE CELL, 2001, 12 (04) :847-862
[2]   Dynamin participates in focal extracellular matrix degradation by invasive cells [J].
Baldassarre, M ;
Pompeo, A ;
Beznoussenko, G ;
Castaldi, C ;
Cortellino, S ;
McNiven, MA ;
Luini, A ;
Buccione, R .
MOLECULAR BIOLOGY OF THE CELL, 2003, 14 (03) :1074-1084
[3]   ENDOCYTOSIS AND RECYCLING OF THE FIBRONECTIN RECEPTOR IN CHO CELLS [J].
BRETSCHER, MS .
EMBO JOURNAL, 1989, 8 (05) :1341-1348
[4]   CIRCULATING INTEGRINS - ALPHA-5-BETA-1, ALPHA-6-BETA-4 AND MAC-1, BUT NOT ALPHA-3-BETA-1, ALPHA-4-BETA-1 OR LFA-1 [J].
BRETSCHER, MS .
EMBO JOURNAL, 1992, 11 (02) :405-410
[5]   Foot and mouth: Podosomes, invadopodia and circular dorsal ruffles [J].
Buccione, R ;
Orth, JD ;
McNiven, MA .
NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2004, 5 (08) :647-657
[6]   Regulated portals of entry into the cell [J].
Conner, SD ;
Schmid, SL .
NATURE, 2003, 422 (6927) :37-44
[7]   Microtubule-induced focal adhesion disassembly is mediated by dynamin and focal adhesion kinase [J].
Ezratty, EJ ;
Partridge, MA ;
Gundersen, GG .
NATURE CELL BIOLOGY, 2005, 7 (06) :581-U15
[8]   Hakai, a c-Cbl-like protein, ubiquitinates and induces endocytosis of the E-cadherin complex [J].
Fujita, Y ;
Krause, G ;
Scheffner, M ;
Zechner, D ;
Leddy, HEM ;
Behrens, J ;
Sommer, T ;
Birchmeier, W .
NATURE CELL BIOLOGY, 2002, 4 (03) :222-231
[9]   Microtubule targeting of substrate contacts promotes their relaxation and dissociation [J].
Kaverina, I ;
Krylyshkina, O ;
Small, JV .
JOURNAL OF CELL BIOLOGY, 1999, 146 (05) :1033-1043
[10]   RhoA is required for cortical retraction and rigidity during mitotic cell rounding [J].
Maddox, AS ;
Burridge, K .
JOURNAL OF CELL BIOLOGY, 2003, 160 (02) :255-265