Mutations in the rpoB gene of multidrug-resistant Mycobacterium tuberculosis clinical isolates from India

被引：108

作者：

Mani, C ^{[1
]}

Selvakumar, N ^{[1
]}

Narayanan, S ^{[1
]}

Narayanan, PR ^{[1
]}

机构：

[1] ICMR, TB Res Ctr, Chetput 600031, Chennai, India

来源：

JOURNAL OF CLINICAL MICROBIOLOGY | 2001年 / 39卷 / 08期

关键词：

D O I：

10.1128/JCM.39.8.2987-2990.2001

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Mutations in the 81-bp rifampin resistance-determining region (RRDR) of the rpoB gene were analyzed by DNA sequencing of 50 Mycobacterium tuberculosis clinical isolates (44 resistant and 6 sensitive) from various parts of India. Fifty-three mutations of 18 different kinds, 17 point mutations and one deletion, were observed in 43 of 44 resistant isolates. Three novel mutations and three new alleles within the RRDR, along with two novel mutations outside the RRDR, are reported in this study.

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页码：2987 / 2990

页数：4

相关论文

共 24 条

[11] THE RPOB GENE OF MYCOBACTERIUM-TUBERCULOSIS [J].

MILLER, LP ;

CRAWFORD, JT ;

SHINNICK, TM .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1994, 38 (04) :805-811

[12] ANTIMICROBIAL AGENT RESISTANCE IN MYCOBACTERIA - MOLECULAR-GENETIC INSIGHTS [J].

MUSSER, JM .

CLINICAL MICROBIOLOGY REVIEWS, 1995, 8 (04) :496-&

[13]

NAIR C N, 1964, Tubercle, V45, P345

[14] rpoB mutations in multidrug-resistant strains of Mycobacterium tuberculosis isolated in Italy [J].

Pozzi, G ;

Meloni, M ;

Iona, E ;

Orrù, G ;

Thoresen, OF ;

Ricci, ML ;

Oggioni, MR ;

Fattorini, L ;

Orefici, G .

JOURNAL OF CLINICAL MICROBIOLOGY, 1999, 37 (04) :1197-1199

[15]

Ramaswamy S., 1998, Tubercle and Lung Disease, V79, P3, DOI 10.1054/tuld.1998.0002

[16]

Schilke K, 1999, INT J TUBERC LUNG D, V3, P620

[17]

SELKON J B, 1960, Bull World Health Organ, V23, P599

[18]

SUBBAIAH T. V., 1960, Tubercle, V41, P323, DOI 10.1016/S0041-3879(60)80034-7

[19] Rifampicin resistance and mutation of the rpoB gene in Mycobacterium tuberculosis [J].

Taniguchi, H ;

Aramaki, H ;

Nikaido, Y ;

Mizuguchi, Y ;

Nakamura, M ;

Koga, T ;

Yoshida, S .

FEMS MICROBIOLOGY LETTERS, 1996, 144 (01) :103-108

[20] DETECTION OF RIFAMPICIN-RESISTANCE MUTATIONS IN MYCOBACTERIUM-TUBERCULOSIS [J].

TELENTI, A ;

IMBODEN, P ;

MARCHESI, F ;

LOWRIE, D ;

COLE, S ;

COLSTON, MJ ;

MATTER, L ;

SCHOPFER, K ;

BODMER, T .

LANCET, 1993, 341 (8846) :647-650