Towards clinical applications of selected reaction monitoring for plasma protein biomarker studies

被引：14

作者：

Krisp, Christoph ^{[2
,3
]}

Randall, Sarah A. ^{[2
]}

McKay, Matthew J. ^{[1
,2
]}

Molloy, Mark P. ^{[1
,2
]}

机构：

[1] Macquarie Univ, APAF, Sydney, NSW 2109, Australia

[2] Macquarie Univ, Dept Chem & Biomol Sci, Sydney, NSW 2109, Australia

[3] Ruhr Univ Bochum, Dept Analyt Chem, Fac Chem & Biochem, Bochum, Germany

来源：

PROTEOMICS CLINICAL APPLICATIONS | 2012年 / 6卷 / 1-2期

基金：

澳大利亚国家健康与医学研究理事会;

关键词：

Biomarker; Plasma; Protein; Selected reaction monitoring; Quantitation; ACUTE MYOCARDIAL-INFARCTION; PROSTATE-SPECIFIC ANTIGEN; PEPTIDE IMMUNOAFFINITY ENRICHMENT; METASTATIC COLORECTAL-CANCER; TARGETED MASS-SPECTROMETRY; M2; PYRUVATE-KINASE; HEAVY-CHAIN; ABSOLUTE QUANTIFICATION; GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE; DIABETIC-RETINOPATHY;

D O I：

10.1002/prca.201100062

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The widespread clinical adoption of protein biomarkers with diagnostic, prognostic and/or predictive value remains a formidable challenge for the biomedical community. From discovery to validation, the path to biomarkers of clinical relevance abounds with many protein candidates, yet so few concrete examples have been substantiated. In this review, we focus on the recent adoption of selected reaction monitoring (SRM) of plasma proteins in the path to clinical use for a broad range of diseases including cancer, cardiovascular disease, genetic disorders and various metabolic disorders. Recent progress reveals a promising outlook for clinical applications using SRM, which now provides the routine analysis of clinically relevant protein markers at low nanogram per millilitre in plasma.

引用

页码：42 / 59

页数：18

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