A heterobimetallic Pd/La/Schiff base complex for anti-selective catalytic asymmetric nitroaldol reactions and applications to short syntheses of β-adrenoceptor agonists

被引：168

作者：

Handa, Shinya ^{[1
]}

Nagawa, Keita ^{[1
]}

Sohtome, Yoshihiro ^{[1
]}

Matsunaga, Shigeki ^{[1
]}

Shibasaki, Masakatsit ^{[1
]}

机构：

[1] Univ Tokyo, Grad Sch Pharmaceut Sci, Bunkyo Ku, Tokyo 1130033, Japan

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2008年 / 47卷 / 17期

关键词：

agonists; amino alcohols; asymmetric catalysis; nitroaldol reaction;

D O I：

10.1002/anie.200705617

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) Two metals in a pod: The combination of Pd and La with a dinucleating Schiff base was developed for anti selectivity in the catalytic asymmetric nitroaldol reaction (see scheme). Short syntheses of β-adrenoceptor agonists by using the heterobimetallic catalyst are presented. © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：3230 / 3233

页数：4

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