Removal of toxic preservatives in pharmaceutical preparations of insulin by the use of ultra-stable zeolite Y

被引：8

作者：

Eriksson, H

机构：

[1] Univ Lund, Wallenberg Lab, Dept Tumor Immunol, S-22007 Lund, Sweden

[2] TEKNOPOL, Ordio AB, Ideon, S-22370 Lund, Sweden

来源：

BIOTECHNOLOGY TECHNIQUES | 1998年 / 12卷 / 04期

关键词：

D O I：

10.1023/A:1008866717990

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Ultra-stable zeolite Y and mordenite with pore sizes of 0.75 and 0.70 nm, respectively, showed the capacity to bind phenol acid m-cresol rapidly. Phenol and m-cresol are used as preservatives in pharmaceutical preparations for humans and, with the use of a 15 mg filter of ultra-stable zeolite Y, 98% of the preservative in a 200 mu l pharmaceutical insulin preparation, Actrapid(R), was removed after 5 s of passage through the filter. The insulin content in the filtrate was not disminished.

引用

页码：329 / 334

页数：6

共 12 条

[1]

ANDERSSON S, 1997, Patent No. 95037313

[2] MYALGIA AND ELEVATED CREATINE-KINASE ACTIVITY ASSOCIATED WITH SUBCUTANEOUS INJECTIONS OF DILUENT [J].