Enzymatic resolution of alicyclic 1,3-amino alcohols in organic media

被引:20
作者
Péter, M
Van der Eycken, J
Bernáth, G
Fülöp, F
机构
[1] State Univ Ghent, Dept Organ Chem, B-9000 Ghent, Belgium
[2] Albert Szent Gyorgyi Med Univ, Inst Pharmaceut Chem, H-6701 Szeged, Hungary
基金
匈牙利科学研究基金会;
关键词
D O I
10.1016/S0957-4166(98)00236-5
中图分类号
O61 [无机化学];
学科分类号
070301 ; 081704 ;
摘要
Racemic cis- and trans-2-aminocyclohexane-1-methanol and cis- and trans-2-amino-4-cyclohexene-1-methanol were resolved via lipase-catalysed O-acylation of their Z derivatives, using vinyl butyrate in different ether solvents. In accordance with the empirical rule, most of the screened lipases preferred the 1S enantiomer. (C) 1998 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:2339 / 2347
页数:9
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