Protective effects of Punica granatum in experimentally-induced gastric ulcers

被引：21

作者：

Alam, Mohd Sarfaraz ^{[2
]}

Alam, Mohd Aftab ^{[2
]}

Ahmad, Sayeed ^{[1
]}

Najmi, Abul Kalam ^{[3
]}

Asif, Mohd ^{[2
]}

Jahangir, Tamanna ^{[1
]}

机构：

[1] Jamia Hamdard, Fac Pharm, Dept Pharmacognosy & Phytochem, New Delhi 110062, India

[2] Jamia Hamdard, Fac Med, Dept Ilmul Advia, New Delhi 110062, India

[3] Jamia Hamdard, Fac Pharm, Dept Pharmacol, New Delhi 110062, India

来源：

TOXICOLOGY MECHANISMS AND METHODS | 2010年 / 20卷 / 09期

关键词：

Gulnar farsi; Punica granatum; anti-ulcer; Unani; ANTIDIARRHEAL ACTIVITY; FLOWERS; BARK; PROSTAGLANDINS; ANTIOXIDANT; FLAVONOIDS; HISTAMINE; EXTRACT; LEAVES; DAMAGE;

D O I：

10.3109/15376516.2010.508079

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 [卫生毒理学];

摘要：

In the present investigation standardized aqueous methanolic extract of Punica (AMP) was used for its possible ulcer protective activity in wistar rats against different experimental models. Preliminary phytochemical screening of AMP reveals the presence of saponin, tannins, and flavonoids, which may be responsible for its activity. HPTLC finger prints of AMP showed the presence of 12 spots at different (retention factor) rf values. Oral administration of AMP (490 and 980 mg/kg bw) significantly reduced the ulcer lesion index produced by alcohol, indomethacin, and aspirin, at both doses in rats. Further, in pylorus-ligated rats AMP significantly reduces the ulcer lesions, gastric volume, and total acidity. It prevents the ulceration by increasing the pH and mucus secretion in pylorus ligated rats. The present study shows the anti-ulcer activity of AMP in experimentally-induced gastric ulcers.

引用

页码：572 / 578

页数：7

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