When orthologs diverge between human and mouse

被引：57

作者：

Gharib, Walid H. ^{[2
]}

Robinson-Rechavi, Marc ^{[1
]}

机构：

[1] Univ Lausanne, Dept Ecol & Evolut, Swiss Inst Bioinformat, CH-1015 Lausanne, Switzerland

[2] Univ Lausanne, Dept Ecol & Evolut, Lab Prof Marc Robinson Rechavi, CH-1015 Lausanne, Switzerland

来源：

BRIEFINGS IN BIOINFORMATICS | 2011年 / 12卷 / 05期

关键词：

orthology; expression divergence; alternative splicing; copy number variants; phenotypic divergence; TRANSCRIPTIONAL REGULATION; LOW CONSERVATION; GENES; EXPRESSION; MICE; EVOLUTION; SELECTION; PHENOTYPES; DROSOPHILA; PROMOTERS;

D O I：

10.1093/bib/bbr031

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Despite the common assumption that orthologs usually share the same function, there have been various reports of divergence between orthologs, even among species as close as mammals. The comparison of mouse and human is of special interest, because mouse is often used as a model organism to understand human biology. We review the literature on evidence for divergence between human and mouse orthologous genes, and discuss it in the context of biomedical research.

引用

页码：436 / 441

页数：6

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