Synthetic virus-like particles from self-assembling coiled-coil lipopeptides and their use in antigen display to the immune system

被引：90

作者：

Boato, Francesca ^{[1
]}

Thomas, Richard M. ^{[1
]}

Ghasparian, Arin ^{[1
]}

Freund-Renard, Annabelle ^{[1
]}

Moehle, Kerstin ^{[1
]}

Robinson, John A. ^{[1
]}

机构：

[1] Univ Zurich, Dept Chem, CH-8057 Zurich, Switzerland

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2007年 / 46卷 / 47期

关键词：

antibodies; antigens; nanostructures; nanotechnology; peptides;

D O I：

10.1002/anie.200702805

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Vanquishing viruses: Access to nanoscale particles is provided by synthetic lipopeptide building blocks that self-assemble into virus-like particles in aqueous solution, and which can be decorated with synthetic antigens for the purpose of generating humoral antigen-specific immune responses in vivo. (Figure Presented). © 2007 Wiley-VCH Verlag GmbH S. Co. KGaA.

引用

页码：9015 / 9018

页数：4

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