pH-Jump Overshooting

被引：18

作者：

Donten, Mateusz L. ^{[1
]}

Hamm, Peter ^{[1
]}

机构：

[1] Univ Zurich, Inst Phys Chem, CH-8057 Zurich, Switzerland

来源：

JOURNAL OF PHYSICAL CHEMISTRY LETTERS | 2011年 / 2卷 / 13期

基金：

瑞士国家科学基金会;

关键词：

PROTON-TRANSFER; AQUEOUS-SOLUTIONS; DEUTERIUM-OXIDE; ACID; KINETICS; DYNAMICS; STATE;

D O I：

10.1021/jz200610n

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Acid base systems are commonly expected to equilibrate on a time scale much faster than any other chemical reaction, so their composition can be deduced from the corresponding pK(a) or pK(b) values. In a pH-jump experiment done on a multi-acid/base pair system, it was found that it takes tens of microseconds before an equilibrium is established. Within that time, the system is kinetically driven, reaching surprising states very different from its final equilibrium; for example, carboxylate groups were protonated in the presence of hydroxyl ions.

引用

页码：1607 / 1611

页数：5

共 36 条

[1] Kinetics of local helix formation in poly-L-glutamic acid studied by time-resolved photoacoustics: Neutralization reactions of carboxylates in aqueous solutions and their relevance to the problem of protein folding [J].

Abbruzzetti, S ;

Viappiani, C ;

Small, JR ;

Libertini, LJ ;

Small, EW .

BIOPHYSICAL JOURNAL, 2000, 79 (05) :2714-2721

[2] Kinetics of acid-induced spectral changes in the GFPmut2 chromophore [J].

Abbruzzetti, S ;

Grandi, E ;

Viappiani, C ;

Bologna, S ;

Campanini, B ;

Raboni, S ;

Bettati, S ;

Mozzarelli, A .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2005, 127 (02) :626-635

[3] Deprotonation yields, pKa, and aci-nitro decay rates in some substituted o-nitrobenzaldehydes [J].

Abbruzzetti, S ;

Carcelli, M ;

Rogolino, D ;

Viappiani, C .

PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES, 2003, 2 (07) :796-800

[4] Acid-induced unfolding of myoglobin triggered by a laser pH jump method [J].

Abbruzzetti, Stefania ;

Sottini, Silvia ;

Viappiani, Cristiano ;

Corrie, John E. T. .

PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES, 2006, 5 (06) :621-628

[5] Real-Time Observation of Carbonic Acid Formation in Aqueous Solution [J].

Adamczyk, Katrin ;

Premont-Schwarz, Mirabelle ;

Pines, Dina ;

Pines, Ehud ;

Nibbering, Erik T. J. .

SCIENCE, 2009, 326 (5960) :1690-1694

[6] THE GROTTHUSS MECHANISM [J].

AGMON, N .

CHEMICAL PHYSICS LETTERS, 1995, 244 (5-6) :456-462

[7]

Atkins PW., 1989, PHYS CHEM

[8] Protein dynamics from time resolved UV Raman spectroscopy [J].

Balakrishnan, Gurusamy ;

Weeks, Colin L. ;

Ibrahim, Mohammed ;

Soldatova, Alexandra V. ;

Spiro, Thomas G. .

CURRENT OPINION IN STRUCTURAL BIOLOGY, 2008, 18 (05) :623-629

[9] Continuous scanning from picoseconds to microseconds in time resolved linear and nonlinear spectroscopy [J].

Bredenbeck, J ;

Helbing, J ;

Hamm, P .

REVIEW OF SCIENTIFIC INSTRUMENTS, 2004, 75 (11) :4462-4466

[10] Nonequilibrium protein folding dynamics: laser-induced pH-jump studies of the-helix-coil transition [J].

Causgrove, TP ;

Dyer, RB .

CHEMICAL PHYSICS, 2006, 323 (01) :2-10

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