Physiological regulation of eukaryotic topoisomerase II

被引：169

作者：

Isaacs, RJ ^{[1
]}

Davies, SL ^{[1
]}

Sandri, MI ^{[1
]}

Redwood, C ^{[1
]}

Wells, NJ ^{[1
]}

Hickson, ID ^{[1
]}

机构：

[1] Univ Oxford, John Radcliffe Hosp, Inst Mol Med, Imperial Canc Res Fund Labs, Oxford OX3 9DS, England

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION | 1998年 / 1400卷 / 1-3期

关键词：

gene expression; promoter; phosphorylation; topoisomerase II; protein kinase; mitosis;

D O I：

10.1016/S0167-4781(98)00131-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Topoisomerase II is an essential enzyme in all organisms with several independent roles in DNA metabolism. In this article we review our knowledge on the regulation of the expression and catalytic activity of topoisomerase II in both lower and higher eukaryotes. Current data indicate that the regulation of topoisomerase II gene expression is complex, with positive and negative controls in evidence at the level of both promoter activity and mRNA stability. Similarly, the activity of the mature enzyme can be regulated by the action of several different protein kinases. Of particular interest is the cell cycle-dependent phosphorylation of topoisomerase II, including multiple, mitosis-specific modifications, which are proposed to regulate the essential chromosome decatenation activity of the enzyme. 0167-4781/98/$ - see front matter (C) 1998 Elsevier Science B.V. All rights reserved.

引用

页码：121 / 137

页数：17

共 85 条

[51] Cell cycle-coupled relocation of types I and II topoisomerases and modulation of catalytic enzyme activities [J].