Ovarian cancer metastasis: Integrating insights from disparate model organisms

被引：438

作者：

Naora, H

Montell, DJ ^{[1
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Dept Biol Chem, Baltimore, MD 21205 USA

[2] Univ Texas, MD Anderson Canc Ctr, Dept Mol Therapeut, Houston, TX 77030 USA

来源：

NATURE REVIEWS CANCER | 2005年 / 5卷 / 05期

关键词：

D O I：

10.1038/nrc1611

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Despite considerable efforts to improve early detection, and advances in chemotherapy, metastasis remains a major challenge in the clinical management of ovarian cancer. Studies of new murine models are providing novel insights into the pathophysiology of ovarian cancer, but these models are not readily amenable to genetic screens. Genetic analysis of border-cell migration in the Drosophila melanogaster ovary provides clues that will improve our understanding of ovarian cancer metastasis at the molecular level, and also might lead to potential therapeutic targets.

引用

收藏

页码：355 / 366

页数：12

相关论文

共 119 条

[51] Cancer statistics, 2004 [J].

Jemal, A ;

Tiwari, RC ;

Murray, T ;

Ghafoor, A ;

Samuels, A ;

Ward, E ;

Feuer, EJ ;

Thun, MJ .

CA-A CANCER JOURNAL FOR CLINICIANS, 2004, 54 (01) :8-29

[52] Epithelial-mesenchymal transitions:: Twist in development and metastasis [J].

Kang, YB ;

Massagué, J .

CELL, 2004, 118 (03) :277-279

[53] Hedgehog signalling in prostate regeneration, neoplasia and metastasis [J].

Karhadkar, SS ;

Bova, GS ;

Abdallah, N ;

Dhara, S ;

Gardner, D ;

Maitra, A ;

Isaacs, JT ;

Berman, DM ;

Beachy, PA .

NATURE, 2004, 431 (7009) :707-712

[54] AIB1/SRC-3 deficiency affects insulin-like growth factor I signaling pathway and suppresses v-Ha-ras-induced breast cancer initiation and progression in mice [J].

Kuang, SQ ;

Liao, L ;

Zhang, H ;

Lee, AV ;

O'Malley, BW ;

Xu, JM .

CANCER RESEARCH, 2004, 64 (05) :1875-1885

[55]

Liu YR, 2001, DEVELOPMENT, V128, P321

[56] The Wnt signaling pathway in development and disease [J].

Logan, CY ;

Nusse, R .

ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, 2004, 20 :781-810

[57] Immunohistochemical patterns for α- and β-catenin, E- and N-cadherin expression in ovarian epithelial tumors [J].

Marques, FR ;

Fonsechi-Carvasan, GA ;

Andrade, LALD ;

Böttcher-Luiz, F .

GYNECOLOGIC ONCOLOGY, 2004, 94 (01) :16-24

[58] PVF1, a PDGF/VEGF homolog, is sufficient to guide border cells and interacts genetically with Taiman [J].

McDonald, JA ;

Pinheiro, EM ;

Montell, DJ .

DEVELOPMENT, 2003, 130 (15) :3469-3478

[59] Role of vascular endothelial growth factor in ovarian cancer -: Inhibition of ascites formation by immunoneutralization [J].

Mesiano, S ;

Ferrara, N ;

Jaffe, RB .

AMERICAN JOURNAL OF PATHOLOGY, 1998, 153 (04) :1249-1256

[60] Genetics of programmed cell death in C-elegans:: past, present and future [J].

Metzstein, MM ;

Stanfield, GM ;

Horvitz, HR .

TRENDS IN GENETICS, 1998, 14 (10) :410-416

← 1 2 3 4 5 6 7 8 9 10 →