Amino acid derivatives of beta-cyclodextrin

被引：266

作者：

Ashton, PR

Koniger, R

Stoddart, JF

Alker, D

Harding, VD

机构：

[1] UNIV BIRMINGHAM,SCH CHEM,BIRMINGHAM B15 2TT,W MIDLANDS,ENGLAND

[2] PFIZER LTD,CENT RES,SANDWICH CT13 9NJ,KENT,ENGLAND

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1996年 / 61卷 / 03期

关键词：

D O I：

10.1021/jo951396d

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The syntheses of the heptaamino acid-substituted beta-cyclodextrins per-6--beta-cyclodextrin (6), per-6-cysteinyl-beta-cyclodextrin (7), as well as the per-2,3-dimethyl-per-6-cysteinyl-beta-cyclodextrin (12) are described. The amino acids were coupled to the primary face of the beta-cyclodextrin torus using the backbone carboxylic acid functionality of phenylalanine and the side chain thiol group of cysteine. In the case of the heptacysteinyl derivatives, polyzwitterionic compounds were obtained and shown to be highly water soluble.

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页码：903 / 908

页数：6

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