Inhibition of the cysteine protease cathepsin K (EC 3.4.22.38)

被引:16
作者
Marquis, RW [1 ]
机构
[1] GlaxoSmithKline, Collegeville, PA 19426 USA
来源
ANNUAL REPORTS IN MEDICINAL CHEMISTRY, VOL 39 | 2004年 / 39卷
关键词
D O I
10.1016/S0065-7743(04)39007-X
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
[No abstract available]
引用
收藏
页码:79 / 98
页数:20
相关论文
共 94 条
[41]   Human cathepsin K cleaves native type I and II collagens at the N-terminal end of the triple helix [J].
Kafienah, W ;
Brömme, D ;
Buttle, DJ ;
Croucher, LJ ;
Hollander, AP .
BIOCHEMICAL JOURNAL, 1998, 331 :727-732
[42]   PARTICIPATION OF CATHEPSIN-L ON BONE-RESORPTION [J].
KAKEGAWA, H ;
NIKAWA, T ;
TAGAMI, K ;
KAMIOKA, H ;
SUMITANI, K ;
KAWATA, T ;
DROBNICKOSOROK, M ;
LENARCIC, B ;
TURK, V ;
KATUNUMA, N .
FEBS LETTERS, 1993, 321 (2-3) :247-250
[43]   (4-Piperidinylphenyl)aminoethyl amides as a novel class of non-covalent cathepsin K inhibitors [J].
Kim, TS ;
Hague, AB ;
Lee, TI ;
Lian, B ;
Tegley, CM ;
Wang, XH ;
Burgess, TL ;
Qian, YX ;
Ross, S ;
Tagari, P ;
Lin, CH ;
Mayeda, C ;
Dao, J ;
Jordan, S ;
Mohr, C ;
Cheetham, J ;
Viswanadhan, V ;
Tasker, AS .
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2004, 14 (01) :87-90
[44]   Use of papain as a model for the structure-based design of cathepsin K inhibitors:: Crystal structures of two papain-inhibitor complexes demonstrate binding to S′-subsites [J].
LaLonde, JM ;
Zhao, BG ;
Smith, WW ;
Janson, CA ;
DesJarlais, RL ;
Tomaszek, TA ;
Carr, TJ ;
Thompson, SK ;
Oh, HJ ;
Yamashita, DS ;
Veber, DF ;
Abdel-Meguid, SS .
JOURNAL OF MEDICINAL CHEMISTRY, 1998, 41 (23) :4567-4576
[45]  
LALONDE JM, 1999, BIOCHEMISTRY-US, V862, P38
[46]   A potent small molecule, nonpeptide inhibitor of cathepsin K (SB 331750) prevents bone matrix resorption in the ovariectomized rat [J].
Lark, MW ;
Stroup, GB ;
James, IE ;
Dodds, RA ;
Hwang, SN ;
Blake, SM ;
Lechowska, BA ;
Hoffman, SJ ;
Smith, BR ;
Kapadia, R ;
Liang, X ;
Erhard, K ;
Ru, Y ;
Dong, X ;
Marquis, RW ;
Veber, D ;
Gowen, M .
BONE, 2002, 30 (05) :746-753
[47]  
Li Y. P., 1994, Molecular Biology of the Cell, V5, p335A
[48]  
LI YP, 1995, J BONE MINER RES, V10, P1197
[49]  
LittlewoodEvans AJ, 1997, CANCER RES, V57, P5386
[50]   CYSTEINE PROTEASE INHIBITION BY AZAPEPTIDE ESTERS [J].
MAGRATH, J ;
ABELES, RH .
JOURNAL OF MEDICINAL CHEMISTRY, 1992, 35 (23) :4279-4283