Inhibition of the cysteine protease cathepsin K (EC 3.4.22.38)

被引：16

作者：

Marquis, RW ^{[1
]}

机构：

[1] GlaxoSmithKline, Collegeville, PA 19426 USA

来源：

ANNUAL REPORTS IN MEDICINAL CHEMISTRY, VOL 39 | 2004年 / 39卷

关键词：

D O I：

10.1016/S0065-7743(04)39007-X

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

[No abstract available]

引用

页码：79 / 98

页数：20

共 94 条

[11] Serum CrossLaps for monitoring the response in individuals undergoing antiresorptive therapy [J].

Christgau, S ;

Bitsch-Jensen, O ;

Bjarnason, NH ;

Henriksen, EG ;

Qvist, P ;

Alexandersen, P ;

Henriksen, DB .

BONE, 2000, 26 (05) :505-511

[12] INHIBITION OF BONE-RESORPTION IN CULTURE BY INHIBITORS OF THIOL PROTEINASES [J].

DELAISSE, JM ;

EECKHOUT, Y ;

VAES, G .

BIOCHEMICAL JOURNAL, 1980, 192 (01) :365-368

[13] INVIVO AND INVITRO EVIDENCE FOR THE INVOLVEMENT OF CYSTEINE PROTEINASES IN BONE-RESORPTION [J].

DELAISSE, JM ;

EECKHOUT, Y ;

VAES, G .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1984, 125 (02) :441-447

[14] Use of X-ray co-crystal structures and molecular modeling to design potent and selective non-peptide inhibitors of cathepsin K [J].

DesJarlais, RL ;

Yamashita, DS ;

Oh, HJ ;

Uzinskas, IN ;

Erhard, KF ;

Allen, AC ;

Haltiwanger, RC ;

Zhao, BG ;

Smith, WW ;

Abdel-Meguid, SS ;

D'Alessio, K ;

Janson, CA ;

McQueney, MS ;

Tomaszek, TA ;

Levy, MA ;

Veber, DF .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1998, 120 (35) :9114-9115

[15]

Dodds RA, 1999, ARTHRITIS RHEUM, V42, P1588, DOI 10.1002/1529-0131(199908)42:8<1588::AID-ANR4>3.0.CO

[16]

2-S

[17] Human osteoclast cathepsin K is processed intracellularly prior to attachment and bone resorption [J].

Dodds, RA ;

James, IE ;

Rieman, D ;

Ahern, R ;

Hwang, SM ;

Connor, JR ;

Thompson, SD ;

Veber, DF ;

Drake, FH ;

Holmes, S ;

Lark, MW ;

Gowen, M .

JOURNAL OF BONE AND MINERAL RESEARCH, 2001, 16 (03) :478-486

[18]

DRAKE F, 1994, J MINER RES, V9, P5177

[19] Cathepsin K, but not cathepsins B, L, or S, is abundantly expressed in human osteoclasts [J].

Drake, FH ;

Dodds, RA ;

James, IE ;

Connor, JR ;

Debouck, C ;

Richardson, S ;

LeeRykaczewski, E ;

Coleman, L ;

Rieman, D ;

Barthlow, R ;

Hastings, G ;

Gowen, M .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (21) :12511-12516

[20] Design and synthesis of diaminopyrrolidinone inhibitors of human osteoclast cathepsin K [J].

Duffy, KJ ;

Ridgers, LH ;

DesJarlais, RL ;

Tomaszek, TA ;

Bossard, MJ ;

Thompson, SK ;

Keenan, RM ;

Veber, DF .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1999, 9 (14) :1907-1910

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