Dairy products and cardiovascular disease

被引:78
作者
Tholstrup, Tine [1 ]
机构
[1] Royal Vet & Agr Univ, Res Dept Human Nutr, Ctr Adv Food Res, Frederiksberg, Denmark
关键词
bioactive peptides; blood pressure; butter; calcium; cheese; cholesterol; coronary heart disease; dairy; fermented; insulin sensitivity; milk; milk fat;
D O I
10.1097/01.mol.0000199813.08602.58
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Purpose of review Although it has often been postulated that the consumption of dairy products is associated with a high risk of coronary heart disease, study results have been conflicting. This review summarizes recent observational and human intervention trial findings on dairy products and cardiovascular disease. Recent findings Results from more recent observational studies on dairy products and milk disagree. This may be because of the very different methods used combined with several methodological problems. A somewhat surprising beneficial association between the intake of dairy products and the metabolic syndrome was observed in some studies, although not in a single study of elderly women. Milk may have the same cholesterol-raising properties as butter, whereas cheese does not seem to increase plasma cholesterol. Some milk products fermented by specific bacterial strains have been shown to have rather moderate cholesterol-reducing properties. There is also good evidence that certain fermented products (especially by Lactobacillus helveticus) have a mildly decreasing effect on hypertension, probably because of bioactive peptides. Summary When guiding principles such as balance; variety and moderation are stressed, there is no strong evidence that dairy products increase the risk of coronary heart disease in healthy men of all ages or young and middle-aged healthy women. Human studies should investigate the role of dairy products with respect to sex and age by including classic and novel risk markers of coronary heart disease. Specific fermented milks may be beneficial in the future prevention of hypertension. The beneficially neutral effect of cheese on coronary heart disease risk factors should be elucidated further.
引用
收藏
页码:1 / 10
页数:10
相关论文
共 89 条
[61]   THE EFFECT OF SKIM MILK, YOGURT, AND FULL CREAM MILK ON HUMAN-SERUM LIPIDS [J].
ROSSOUW, JE ;
BURGER, EM ;
VANDERVYVER, P ;
FERREIRA, JJ .
AMERICAN JOURNAL OF CLINICAL NUTRITION, 1981, 34 (03) :351-356
[62]   Dietary fat intake in healthy adolescents: inverse relationships between the estimated intake of saturated fatty acids and serum cholesterol [J].
Samuelson, G ;
Bratteby, LE ;
Mohsen, R ;
Vessby, B .
BRITISH JOURNAL OF NUTRITION, 2001, 85 (03) :333-341
[63]   Effects of a milk product, fermented by Lactobacillus acidophilus and with fructo-oligosaccharides added, on blood lipids in male volunteers [J].
Schaafsma, G ;
Meuling, WJA ;
van Dokkum, W ;
Bouley, C .
EUROPEAN JOURNAL OF CLINICAL NUTRITION, 1998, 52 (06) :436-440
[64]   DIET AND CORONARY ARTERIAL-DISEASE - A STATISTICAL STUDY [J].
SEELY, S .
INTERNATIONAL JOURNAL OF CARDIOLOGY, 1988, 20 (02) :183-192
[65]   A fermented milk high in bioactive peptides has a blood pressure-lowering effect in hypertensive subjects [J].
Seppo, L ;
Jauhiainen, T ;
Poussa, T ;
Korpela, R .
AMERICAN JOURNAL OF CLINICAL NUTRITION, 2003, 77 (02) :326-330
[66]  
Shahkhalili Y, 2001, AM J CLIN NUTR, V73, P246
[67]  
Shi H, 2001, FASEB J, V15, P291
[68]   Milk-derived fatty acids are associated with a more favorable LDL particle size distribution in healthy men [J].
Sjogren, P ;
Rosell, M ;
Skoglund-Andersson, C ;
Zdravkovic, S ;
Vessby, B ;
de Faire, U ;
Hamsten, A ;
Hellenius, ML ;
Fisher, RM .
JOURNAL OF NUTRITION, 2004, 134 (07) :1729-1735
[69]   Consumption of fermented and nonfermented dairy products: effects on cholesterol concentrations and metabolism [J].
St-Onge, MP ;
Farnworth, ER ;
Jones, PJH .
AMERICAN JOURNAL OF CLINICAL NUTRITION, 2000, 71 (03) :674-681
[70]   EFFECT OF CONSUMPTION OF WHOLE MILK AND SKIM MILK ON BLOOD LIPID PROFILES IN HEALTHY-MEN [J].
STEINMETZ, KA ;
CHILDS, MT ;
STIMSON, C ;
KUSHI, LH ;
MCGOVERN, PG ;
POTTER, JD ;
YAMANAKA, WK .
AMERICAN JOURNAL OF CLINICAL NUTRITION, 1994, 59 (03) :612-618