Biological activity of flavonoids copper complexes

被引：14

作者：

González-Alvarez, M

Alzuet, G

García-Giménez, JL

Macías, B

Borrás, J

机构：

[1] Univ Valencia, Fac Farm, Dept Quim Inorgan, E-46100 Burjassot, Spain

[2] Univ Salamanca, Fac Farm, Dept Quim Inorgan, E-37007 Salamanca, Spain

来源：

ZEITSCHRIFT FUR ANORGANISCHE UND ALLGEMEINE CHEMIE | 2005年 / 631卷 / 11期

关键词：

copper; flavonoids; nuclease activity; reactive oxygen species; superoxide dismutase activity;

D O I：

10.1002/zaac.200570037

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Three flavonoid copper(II) complexes Cu-2(quercetin)(CH3COO)(3)(CH3OH) (1), Cu(anthrarufin)(CH3COO)(.)1/2H(2)O (2) and Cu(naringin)(OCH3)(CH3OH)(2) (3) have been synthesized and characterized by elemental analysis, IR, electronic absorption and EPR (X-band) spectroscopy. The complexes have a strong protective action over the Delta sod1 mutant of S. cerevisiae against reactive oxygen radicals generated by an external source of free radicals (H2O2 or the superoxide-generating, menadione). On the other hand, the complexes cleave DNA efficiently even in the absence of reducing agents. The main reactive oxygen species responsible for the DNA strand cleavage have been determined using radical scavengers. A probably mechanism of the DNA damage is proposed.

引用

收藏

页码：2181 / 2187

页数：7

相关论文

共 42 条

[1] MODE OF BINDING OF QUERCETIN TO DNA [J].

AHMED, MS ;

RAMESH, V ;

NAGARAJA, V ;

PARISH, JH ;

HADI, SM .

MUTAGENESIS, 1994, 9 (03) :193-197

[2] Preparation and oxygenation of (flavonolato)copper isoindoline complexes with relevance to quercetin dioxygenase [J].

Balogh-Hergovich, É ;

Kaizer, J ;

Speier, G ;

Huttner, G ;

Jacobi, A .

INORGANIC CHEMISTRY, 2000, 39 (19) :4224-4229

[3] Kinetic studies on the copper(II)-mediated oxygenolysis of the flavonolate ligand.: Crystal structures of [Cu(fla)2] (fla = flavonolate) and [Cu(O-bs)2(py)3] (O-bs = O-benzoylsalicylate) [J].

Balogh-Hergovich, É ;

Kaizer, J ;

Speier, G ;

Argay, G ;

Párkányi, L .

JOURNAL OF THE CHEMICAL SOCIETY-DALTON TRANSACTIONS, 1999, (21) :3847-3854

[4] Quercetin 2,3-dioxygenase mimicking ring cleavage of the flavonolate ligand assisted by copper.: Synthesis and characterization of copper(I) complexes [Cu(PPh3)2(fla)] (fla = flavonolate) and [Cu(PPh3)2(O-bs)] (O-bs = O-benzoylsalicylate) [J].

Balogh-Hergovich, É ;

Kaizer, J ;

Speier, G ;

Fülöp, V ;

Párkányi, L .

INORGANIC CHEMISTRY, 1999, 38 (17) :3787-3795

[5] Carboxylate-enhanced reactivity in the oxygenation of copper flavonolate complexes [J].

Balogh-Hergovich, É ;

Kaizer, J ;

Speier, G .

JOURNAL OF MOLECULAR CATALYSIS A-CHEMICAL, 2003, 206 (1-2) :83-87

[6]

Balogh-Hergovich É, 2002, EUR J INORG CHEM, P2287

[7] THE OXYGENATION OF FLAVONOL BY COPPER(I) AND COPPER(II) FLAVONOLATE COMPLEXES - THE CRYSTAL AND MOLECULAR-STRUCTURE OF BIS(FLAVONOLATO)COPPER(II) [J].

BALOGHHERGOVICH, E ;

SPEIER, G ;

ARGAY, G .

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1991, (08) :551-552

[8] Synthesis and characterization of copper(I) and copper(II) flavonolate complexes with phthalazine ligand, and their oxygenation and relevance to quercetinase [J].

BaloghHergovich, E ;

Kaizer, J ;

Speier, G .

INORGANICA CHIMICA ACTA, 1997, 256 (01) :9-14

[9] Kinetics and mechanism of the stoichiometric oxygenation of [CuII(fla)(idpa)]ClO4 [fla = flavonolate, idpa=3,3′-imino-bis(N,N-dimethylpropylamine)] and the [CuII(fla)(idpa)]ClO4-catalysed oxygenation of flavonol [J].

Barhács, L ;

Kaizer, J ;

Pap, J ;

Speier, G .

INORGANICA CHIMICA ACTA, 2001, 320 (1-2) :83-91

[10] TRIS(PHENANTHROLINE)RUTHENIUM(II) - STEREOSELECTIVITY IN BINDING TO DNA [J].

BARTON, JK ;

DANISHEFSKY, AT ;

GOLDBERG, JM .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1984, 106 (07) :2172-2176

← 1 2 3 4 5 →