Measuring target effect of proposed disease-modifying therapies in Alzheimer's disease

被引:22
作者
Bateman, Randall J. [1 ]
Klunk, William E. [2 ]
机构
[1] Washington Univ, Sch Med, Dept Neurol, St Louis, MO 63110 USA
[2] Univ Pittsburgh, Sch Med, Dept Psychiat, Pittsburgh, PA 15213 USA
关键词
Alzheimer's disease; Alzheimer; treatment; biomarker; amyloid; amyloid-beta; CSF; cerebrospinal fluid; therapeutic; kinetics; production; clearance; PET; PiB;
D O I
10.1016/j.nurt.2008.05.009
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Alzheimer's disease (AD) is the most common cause of dementia and is an increasing public health problem. Because of the severity and increasing prevalence of the disease in the population, it is urgent that better treatments be developed. Active research efforts over the past several decades have produced a vast knowledge base regarding AD natural history, pathology, and key biological mediators involved in pathogenesis. As knowledge of the biomolecular mechanisms of AD has increased over the past several decades, there has been a growing consensus on the pathophysiology of the disease. These scientific advancements have led to proposals for disease-modifying therapeutic interventions that promise to significantly alter the course of AD. The translation from preclinical models to human studies requires therapeutic biomarkers to increase the likelihood of success. This review covers the current methods and technologies used in the therapeutic translation of proposed disease-modifying therapies for AD.
引用
收藏
页码:381 / 390
页数:10
相关论文
共 105 条
[91]   Effects of a γ-secretase inhibitor in a randomized study of patients with Alzheimer disease [J].
Siemers, ER ;
Quinn, JF ;
Kaye, J ;
Farlow, MR ;
Porsteinsson, A ;
Tariot, P ;
Zoulnouni, P ;
Galvin, JE ;
Holtzman, DM ;
Knopman, DS ;
Satterwhite, J ;
Gonzales, C ;
Dean, RA ;
May, PC .
NEUROLOGY, 2006, 66 (04) :602-604
[92]   APP duplication is sufficient to cause early onset Alzheimer's dementia with cerebral amyloid angiopathy [J].
Sleegers, Kristel ;
Brouwers, Nathalie ;
Gijselinck, Ilse ;
Theuns, Jessie ;
Goossens, Dirk ;
Wauters, Jan ;
Del-Favero, Jurgen ;
Cruts, Marc ;
van Duijn, Cornelia M. ;
Van Broeckhoven, Christine .
BRAIN, 2006, 129 :2977-2983
[93]   PET of brain amyloid and tau in mild cognitive impairment [J].
Small, Gary W. ;
Kepe, Vladimir ;
Ercoli, Linda M. ;
Siddarth, Prabha ;
Bookheimer, Susan Y. ;
Miller, Karen J. ;
Lavretsky, Helen ;
Burggren, Alison C. ;
Cole, Greg M. ;
Vinters, Harry V. ;
Thompson, Paul M. ;
Huang, S. -C. ;
Satyamurthy, N. ;
Phelps, Michael E. ;
Barrio, Jorge R. .
NEW ENGLAND JOURNAL OF MEDICINE, 2006, 355 (25) :2652-2663
[94]   Transgenic models of Alzheimer's disease: Learning from animals [J].
Spires T.L. ;
Hyman B.T. .
NeuroRX, 2005, 2 (3) :423-437
[95]  
Sunderland T, 2007, JAMA-J AM MED ASSOC, V298, P1516
[96]   Decreased β-amyloid1-42 and increased tau levels in cerebrospinal fluid of patients with Alzheimer disease [J].
Sunderland, T ;
Linker, G ;
Mirza, N ;
Putnam, KT ;
Friedman, DL ;
Kimmel, LH ;
Bergeson, J ;
Manetti, GJ ;
Zimmermann, M ;
Tang, B ;
Bartko, JJ ;
Cohen, RM .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2003, 289 (16) :2094-2103
[97]   Prednisolone (30-60 mg/day) for diseases other than AD decreases amyloid β-peptides in CSF [J].
Tokuda, T ;
Oide, T ;
Tamaoka, A ;
Ishii, K ;
Matsuno, S ;
Ikeda, S .
NEUROLOGY, 2002, 58 (09) :1415-1418
[98]   Neuronal or glial expression of human apolipoprotein E4 affects parenchymal and vascular amyloid pathology differentially in different brain regions of double- and triple-transgenic mice [J].
Van Dooren, T ;
Muyllaert, D ;
Borghgraef, P ;
Cresens, A ;
Devijver, H ;
Van der Auwera, I ;
Wera, S ;
Dewachter, I ;
Van Leuven, F .
AMERICAN JOURNAL OF PATHOLOGY, 2006, 168 (01) :245-260
[99]   β-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE [J].
Vassar, R ;
Bennett, BD ;
Babu-Khan, S ;
Kahn, S ;
Mendiaz, EA ;
Denis, P ;
Teplow, DB ;
Ross, S ;
Amarante, P ;
Loeloff, R ;
Luo, Y ;
Fisher, S ;
Fuller, L ;
Edenson, S ;
Lile, J ;
Jarosinski, MA ;
Biere, AL ;
Curran, E ;
Burgess, T ;
Louis, JC ;
Collins, F ;
Treanor, J ;
Rogers, G ;
Citron, M .
SCIENCE, 1999, 286 (5440) :735-741
[100]   In-vivo imaging of Alzheimer disease β-amyloid with [11C]SB-13 PET [J].
Verhoeff, NPLG ;
Wilson, AA ;
Takeshita, S ;
Trop, L ;
Hussey, D ;
Singh, K ;
Kung, HF ;
Kung, MP ;
Houle, S .
AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY, 2004, 12 (06) :584-595