Synthesis of an isochroman analogue of the michellamines

被引：37

作者：

de Koning, CB ^{[1
]}

Michael, JP ^{[1
]}

van Otterlo, WAL ^{[1
]}

机构：

[1] Univ Witwatersrand, Dept Chem, Ctr Mol Design, ZA-2050 Wits, South Africa

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 15期

关键词：

biaryls; naphthalenes; isochromans; Suzuki coupling;

D O I：

10.1016/S0040-4039(99)00318-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of racemic 5-iodo-6, 8-dimethoxy-1,3-trans-dimethylisochroman (16) in eleven steps from 2,4-dimethoxybenzaldehyde is outlined. Compound (16) was coupled by means of Suzuki methodology with 4-isopropoxy-5-methoxy-7-methylnaphthaleneboronic acid (19) to yield (20). This was converted into (6), a racemic isochroman analogue of the michellamines. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：3037 / 3040

页数：4

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