Structural analogues of the michellamine anti-HIV agents. Importance of the tetrahydroisoquinoline rings for biological activity

被引：24

作者：

Zhang, HP ^{[1
]}

Zembower, DE ^{[1
]}

Chen, ZD ^{[1
]}

机构：

[1] MEDICHEM RES INC,LEMONT,IL 60439

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1997年 / 7卷 / 20期

关键词：

D O I：

10.1016/S0960-894X(97)10057-9

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of michellamine structural analogues was prepared in which the tetrahydroisoquinoline rings were substituted with a variety of simple aromatic ring systems. Additionally, the methyl groups on the central bis-naphthalene cores were replaced with hydrogen and methoxy. All the analogues were devoid of anti-HIV activity, suggesting that the heterocyclic portion of the tetrahydroisoquinoline ring is crucial for biological activity. (C) 1997 Elsevier Science Ltd.

引用

页码：2687 / 2690

页数：4

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