Phosphodiesterase type 5 (PDE5) in the adipocyte: a novel player in fat metabolism?

被引：50

作者：

Armani, Andrea ^{[1
]}

Marzolla, Vincenzo ^{[2
]}

Rosano, Giuseppe M. C. ^{[1
]}

Fabbri, Andrea ^{[3
]}

Caprio, Massimiliano ^{[1
]}

机构：

[1] Sci Inst Res Hospitalizat & Hlth Care IRCCS San R, Ctr Clin & Basic Res, Rome, Italy

[2] San Raffaele Sulmona, Sulmona, AQ, Italy

[3] Univ Roma Tor Vergata, Endocrinol Unit, St Eugenio & CTO A Alesini Hosp, Rome, Italy

来源：

TRENDS IN ENDOCRINOLOGY AND METABOLISM | 2011年 / 22卷 / 10期

关键词：

NITRIC-OXIDE; ADIPOSE-TISSUE; AROMATASE EXPRESSION; PROTEIN-KINASE; CREB PHOSPHORYLATION; NATRIURETIC PEPTIDES; ADIPOGENESIS; CGMP; ACTIVATION; ESTROGEN;

D O I：

10.1016/j.tem.2011.05.004

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Phosphodiesterase type 5 (PDE5) is expressed in many tissues (e.g. heart, lung, pancreas, penis) and plays a specific role in hydrolyzing cyclic guanosine monophosphate (cGMP). In adipocytes, cGMP regulates crucial functions by activating cGMP-dependent protein kinase (PKG). Interestingly, PDE5 was recently identified in adipose tissue, although its role remains unclear. Its inhibition, however, was recently shown to affect adipose differentiation and aromatase function. This review summarizes evidence supporting a role for the PDE5-regulated cGMP/PKG system in adipose tissue and its effects on adipocyte function. A better elucidation of the role of PDE5 in the adipocyte could reveal new therapeutic strategies for fighting obesity and metabolic syndrome.

引用

页码：404 / 411

页数：8

共 72 条

[1] Rho-Kinase/ROCK: A Key Regulator of the Cytoskeleton and Cell Polarity [J].

Amano, Mutsuki ;

Nakayama, Masanori ;

Kaibuchi, Kozo .

CYTOSKELETON, 2010, 67 (09) :545-554

[2] p38MAP Kinase activity is required for human primary adipocyte differentiation [J].

Aouadi, M. ;

Jager, J. ;

Laurent, K. ;

Gonzalez, T. ;

Cormont, M. ;

Binetruy, B. ;

Le Marchand-Brustel, Y. ;

Tanti, J. -F. ;

Bost, F. .

FEBS LETTERS, 2007, 581 (29) :5591-5596

[3] Exposure to Phosphodiesterase Type 5 Inhibitors Stimulates Aromatase Expression in Human Adipocytes in vitro [J].

Aversa, Antonio ;

Caprio, Massimiliano ;

Antelmi, Antonella ;

Armani, Andrea ;

Brama, Marina ;

Greco, Emanuela A. ;

Francomano, Davide ;

Calanchini, Matilde ;

Spera, Giovanni ;

Di Luigi, Luigi ;

Rosano, Giuseppe M. C. ;

Lenzi, Andrea ;

Migliaccio, Silvia ;

Fabbri, Andrea .

JOURNAL OF SEXUAL MEDICINE, 2011, 8 (03) :696-704

[4] Chronic treatment with sildenafil improves energy balance and insulin action in high fat-fed conscious mice [J].

Ayala, Julio E. ;

Bracy, Deanna P. ;

Julien, Brianna M. ;

Rottman, Jeffrey N. ;

Fueger, Patrick T. ;

Wasserman, David H. .

DIABETES, 2007, 56 (04) :1025-1033

[5] Cyclic nucleotide research - still expanding after half a century [J].

Beavo, JA ;

Brunton, LL .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2002, 3 (09) :710-718

[6] Insulin stimulates glucose transport via nitric oxide/cyclic GMP pathway in human vascular smooth muscle cells [J].

Bergandi, L ;

Silvagno, F ;

Russo, I ;

Riganti, C ;

Anfossi, G ;

Aldieri, E ;

Ghigo, D ;

Trovati, M ;

Bosia, A .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2003, 23 (12) :2215-2221

[7]

CAPRIO M, 2010, J ENDOCRINOL INVES S, V33, P46

[8] Nitric oxide regulates cGMP-dependent cAMP-responsive element binding protein phosphorylation and Bcl-2 expression in cerebellar neurons: implication for a survival role of nitric oxide [J].

Ciani, E ;

Guidi, S ;

Bartesaghi, R ;

Contestabile, A .

JOURNAL OF NEUROCHEMISTRY, 2002, 82 (05) :1282-1289

[9] Reversible physiological transdifferentiation in the adipose organ [J].

Cinti, Saverio .

PROCEEDINGS OF THE NUTRITION SOCIETY, 2009, 68 (04) :340-349

[10] High lung PDE5: A strong basis for treating pulmonary hypertension with PDE5 inhibitors [J].

Corbin, JD ;

Beasley, A ;

Blount, MA ;

Francis, SH .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2005, 334 (03) :930-938

← 1 2 3 4 5 6 7 8 →