Surface-induced droplet fusion in microfluidic devices

被引:167
作者
Fidalgo, Luis M.
Abell, Chris
Huck, Wilhelm T. S.
机构
[1] Univ Cambridge, Dept Chem, Melville Lab Polymer Synth, Cambridge CB2 1EW, England
[2] Univ Cambridge, Dept Chem, Cambridge CB2 1EW, England
基金
英国工程与自然科学研究理事会;
关键词
D O I
10.1039/b708091c
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
Here we demonstrate a new method for droplet fusion based on a surface energy pattern on the walls of a microfluidic device, that does not require active elements nor accurate synchronization of the droplets.
引用
收藏
页码:984 / 986
页数:3
相关论文
共 20 条
[11]   Reactions in droplets in microflulidic channels [J].
Song, Helen ;
Chen, Delai L. ;
Ismagilov, Rustem F. .
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2006, 45 (44) :7336-7356
[12]   Design of microfluidic channel geometries for the control of droplet volume, chemical concentration, and sorting [J].
Tan, YC ;
Fisher, JS ;
Lee, AI ;
Cristini, V ;
Lee, AP .
LAB ON A CHIP, 2004, 4 (04) :292-298
[13]   Dynamic pattern formation in a vesicle-generating microfluidic device [J].
Thorsen, T ;
Roberts, RW ;
Arnold, FH ;
Quake, SR .
PHYSICAL REVIEW LETTERS, 2001, 86 (18) :4163-4166
[14]   Monodisperse emulsion generation via drop break off in a coflowing stream [J].
Umbanhowar, PB ;
Prasad, V ;
Weitz, DA .
LANGMUIR, 2000, 16 (02) :347-351
[15]   Covalent micropatterning of poly(dimethylsiloxane) by photografting through a mask [J].
Wang, YL ;
Lai, HH ;
Bachman, M ;
Sims, CE ;
Li, GP ;
Allbritton, NL .
ANALYTICAL CHEMISTRY, 2005, 77 (23) :7539-7546
[16]  
Xia YN, 1998, ANGEW CHEM INT EDIT, V37, P550, DOI 10.1002/(SICI)1521-3773(19980316)37:5<550::AID-ANIE550>3.0.CO
[17]  
2-G
[18]   Screening of protein crystallization conditions on a microfluidic chip using nanoliter-size droplets [J].
Zheng, B ;
Roach, LS ;
Ismagilov, RF .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2003, 125 (37) :11170-11171
[19]   A microfluidic approach for screening submicroliter volumes against multiple reagents by using preformed arrays of nanoliter plugs in a three-phase liquid/liquid/gas flow [J].
Zheng, B ;
Ismagilov, RF .
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2005, 44 (17) :2520-2523
[20]   Formation of droplets of in microfluidic channels alternating composition and applications to indexing of concentrations in droplet-based assays [J].
Zheng, B ;
Tice, JD ;
Ismagilov, RF .
ANALYTICAL CHEMISTRY, 2004, 76 (17) :4977-4982