A microfluidic approach for screening submicroliter volumes against multiple reagents by using preformed arrays of nanoliter plugs in a three-phase liquid/liquid/gas flow

被引：195

作者：

Zheng, B ^{[1
]}

Ismagilov, RF ^{[1
]}

机构：

[1] Univ Chicago, Dept Chem, Chicago, IL 60637 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2005年 / 44卷 / 17期

关键词：

crystal growth; enzymatic arrays; microreactors; screening methods; three-phase system;

D O I：

10.1002/anie.200462857

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Graph Presented) Plugging a gap in screening: Arrays of nanoliter-sized plugs of different compositions can be preformed in a three-phase liquid/liquid/gas flow. The arrays can be transported into a microfluidic channel to test against a target (see schematic representation), as demonstrated in protein crystallization and an enzymatic assay. © 2005 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：2520 / 2523

页数：4

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