A facile route to paclitaxel C-10 carbamates

被引：7

作者：

Ballatore, C ^{[1
]}

Aspland, SE

Castillo, R

Desharnais, J

Eustaquio, T

Sun, SZ

Castellino, AJ

Smith, AB

机构：

[1] Acidophil LLC, Suite 250,10835 Rd Cure, San Diego, CA 92121 USA

[2] Drexel Univ, Dept Chem, Philadelphia, PA 19104 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2005年 / 15卷 / 10期

关键词：

D O I：

10.1016/j.bmcl.2005.03.072

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A general protocol for the synthesis of paclitaxel C-10 carbamates is described. The method entails MeI-mediated activation of 2'-O-TBS-7-O-TES-10-O-deacetyl-paclitaxel-10-O-carbonylimidazole prior to reaction with amines. This method is effective for the synthesis of paclitaxel C-10 derivatives, including bifunctional molecules. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：2477 / 2480

页数：4

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