The thioredoxin system in retroviral infection and apoptosis

被引：91

作者：

Masutani, H

Ueda, S

Yodoi, J

机构：

[1] Kyoto Univ, Inst Virus Res, Dept Biol Responses, Sakyo Ku, Kyoto 6068507, Japan

[2] Kyoto Univ Hosp, Translat Res Ctr, Dept Expt Therapeut, Thioredoxin Project,Sakyo Ku, Kyoto 606, Japan

来源：

CELL DEATH AND DIFFERENTIATION | 2005年 / 12卷 / Suppl 1期

关键词：

thioredoxin; thioredoxin-binding protein-2 (TBP-2)/vitamin D-3 upregulated protein-1 (VDUP1); apoptosis; apoptosis signal-regulating kinase 1 (ASK1); HIV; HTLV-I;

D O I：

10.1038/sj.cdd.4401625

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Human thioredoxin (TRX) was first identified in human T-cell leukemia virus type I (HTLV-I)-positive T-cell lines and is associated with the pathophysiology of retroviral infections. TRX is a vital component of the thiol-reducing system and regulates various cellular function ( redox regulation). Members of the TRX system regulate apoptosis through a wide variety of mechanisms. A family of thioredoxin-dependent peroxidases (peroxiredoxins) protects against apoptosis by scavenging hydrogen peroxide. Thioredoxin 2 is a critical regulator of cytochrome c release and mitochondrial apoptosis; transmembrane thioredoxin-related molecule (TMX) has a protective role in endoplasmic reticulum ( ER) stress-induced apoptosis. TRX interacts with apoptosis signal-regulating kinase 1 (ASK1) and is a sensor of oxidative stress. Thioredoxin binding protein-2/vitamin D-3 upregulated protein 1 is a growth suppressor and its expression is suppressed in HTLV-I-transformed cells. Studies of these molecules of the TRX system provide novel insights into the apoptosis associated with retroviral diseases.

引用

页码：991 / 998

页数：8

共 93 条

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