共 26 条
Reversible oxidative modification as a mechanism for regulating retroviral protease dimerization and activation
被引:41
作者:

Davis, DA
论文数: 0 引用数: 0
h-index: 0
机构: NCI, CCR, HIV & AIDS Malignancy Branch, NIH, Bethesda, MD 20892 USA

Brown, CA
论文数: 0 引用数: 0
h-index: 0
机构: NCI, CCR, HIV & AIDS Malignancy Branch, NIH, Bethesda, MD 20892 USA

Newcomb, FM
论文数: 0 引用数: 0
h-index: 0
机构: NCI, CCR, HIV & AIDS Malignancy Branch, NIH, Bethesda, MD 20892 USA

Boja, ES
论文数: 0 引用数: 0
h-index: 0
机构: NCI, CCR, HIV & AIDS Malignancy Branch, NIH, Bethesda, MD 20892 USA

Fales, HM
论文数: 0 引用数: 0
h-index: 0
机构: NCI, CCR, HIV & AIDS Malignancy Branch, NIH, Bethesda, MD 20892 USA

Kaufman, J
论文数: 0 引用数: 0
h-index: 0
机构: NCI, CCR, HIV & AIDS Malignancy Branch, NIH, Bethesda, MD 20892 USA

Stahl, SJ
论文数: 0 引用数: 0
h-index: 0
机构: NCI, CCR, HIV & AIDS Malignancy Branch, NIH, Bethesda, MD 20892 USA

Wingfield, P
论文数: 0 引用数: 0
h-index: 0
机构: NCI, CCR, HIV & AIDS Malignancy Branch, NIH, Bethesda, MD 20892 USA

Yarchoan, R
论文数: 0 引用数: 0
h-index: 0
机构: NCI, CCR, HIV & AIDS Malignancy Branch, NIH, Bethesda, MD 20892 USA
机构:
[1] NCI, CCR, HIV & AIDS Malignancy Branch, NIH, Bethesda, MD 20892 USA
[2] NHLBI, Lab Biophys Chem, NIH, Bethesda, MD 20892 USA
[3] NIAMSD, Prot Express Lab, NIH, Bethesda, MD 20892 USA
关键词:
D O I:
10.1128/JVI.77.5.3319-3325.2003
中图分类号:
Q93 [微生物学];
学科分类号:
071005 ;
100705 ;
摘要:
Human immunodeficiency virus protease activity can be regulated by reversible oxidation of a sulfur-containing amino acid at the dimer interface. We show here that oxidation of this amino acid in human immunodeficiency virus type I protease prevents dimer formation. Moreover, we show that human T-cell leukemia virus type I protease can be similarly regulated through reversible glutathionylation of its two conserved cysteine residues. Based on the known three-dimensional structures and multiple sequence alignments of retroviral proteases, it is predicted that the majority of retroviral proteases have sulfur-containing amino acids at the dimer interface. The regulation of protease activity by the modification of a sulfur-containing amino acid at the dimer interface may be a conserved mechanism among the majority of retroviruses.
引用
收藏
页码:3319 / 3325
页数:7
相关论文
共 26 条
[1]
HIV-1 PROTEASE CLEAVES ACTIN DURING ACUTE INFECTION OF HUMAN LYMPHOCYTES-T
[J].
ADAMS, LD
;
TOMASSELLI, AG
;
ROBBINS, P
;
MOSS, B
;
HEINRIKSON, RL
.
AIDS RESEARCH AND HUMAN RETROVIRUSES,
1992, 8 (02)
:291-295

ADAMS, LD
论文数: 0 引用数: 0
h-index: 0
机构:
NIAID,VIRAL DIS LAB,BETHESDA,MD 20892 NIAID,VIRAL DIS LAB,BETHESDA,MD 20892

TOMASSELLI, AG
论文数: 0 引用数: 0
h-index: 0
机构:
NIAID,VIRAL DIS LAB,BETHESDA,MD 20892 NIAID,VIRAL DIS LAB,BETHESDA,MD 20892

ROBBINS, P
论文数: 0 引用数: 0
h-index: 0
机构:
NIAID,VIRAL DIS LAB,BETHESDA,MD 20892 NIAID,VIRAL DIS LAB,BETHESDA,MD 20892

MOSS, B
论文数: 0 引用数: 0
h-index: 0
机构:
NIAID,VIRAL DIS LAB,BETHESDA,MD 20892 NIAID,VIRAL DIS LAB,BETHESDA,MD 20892

HEINRIKSON, RL
论文数: 0 引用数: 0
h-index: 0
机构:
NIAID,VIRAL DIS LAB,BETHESDA,MD 20892 NIAID,VIRAL DIS LAB,BETHESDA,MD 20892
[2]
Conserved cysteines of the human immunodeficiency virus type 1 protease are involved in regulation of polyprotein processing and viral maturation of immature virions
[J].
Davis, DA
;
Yusa, K
;
Gillim, LA
;
Newcomb, FM
;
Mitsuya, H
;
Yarchoan, R
.
JOURNAL OF VIROLOGY,
1999, 73 (02)
:1156-1164

Davis, DA
论文数: 0 引用数: 0
h-index: 0
机构: NCI, HIV & AIDS Malignancy Branch, Bethesda, MD 20892 USA

Yusa, K
论文数: 0 引用数: 0
h-index: 0
机构: NCI, HIV & AIDS Malignancy Branch, Bethesda, MD 20892 USA

Gillim, LA
论文数: 0 引用数: 0
h-index: 0
机构: NCI, HIV & AIDS Malignancy Branch, Bethesda, MD 20892 USA

Newcomb, FM
论文数: 0 引用数: 0
h-index: 0
机构: NCI, HIV & AIDS Malignancy Branch, Bethesda, MD 20892 USA

Mitsuya, H
论文数: 0 引用数: 0
h-index: 0
机构: NCI, HIV & AIDS Malignancy Branch, Bethesda, MD 20892 USA

Yarchoan, R
论文数: 0 引用数: 0
h-index: 0
机构: NCI, HIV & AIDS Malignancy Branch, Bethesda, MD 20892 USA
[3]
Thioltransferase (glutaredoxin) is detected-within HIV-1 and can regulate the activity of glutathionylated HIV-1 protease in vitro
[J].
Davis, DA
;
Newcomb, FM
;
Starke, DW
;
Ott, DE
;
Mieyal, JJ
;
Yarchoan, R
.
JOURNAL OF BIOLOGICAL CHEMISTRY,
1997, 272 (41)
:25935-25940

Davis, DA
论文数: 0 引用数: 0
h-index: 0
机构: CASE WESTERN RESERVE UNIV,SCH MED,DEPT PHARMACOL,CLEVELAND,OH 44106

Newcomb, FM
论文数: 0 引用数: 0
h-index: 0
机构: CASE WESTERN RESERVE UNIV,SCH MED,DEPT PHARMACOL,CLEVELAND,OH 44106

Starke, DW
论文数: 0 引用数: 0
h-index: 0
机构: CASE WESTERN RESERVE UNIV,SCH MED,DEPT PHARMACOL,CLEVELAND,OH 44106

Ott, DE
论文数: 0 引用数: 0
h-index: 0
机构: CASE WESTERN RESERVE UNIV,SCH MED,DEPT PHARMACOL,CLEVELAND,OH 44106

Mieyal, JJ
论文数: 0 引用数: 0
h-index: 0
机构: CASE WESTERN RESERVE UNIV,SCH MED,DEPT PHARMACOL,CLEVELAND,OH 44106

Yarchoan, R
论文数: 0 引用数: 0
h-index: 0
机构: CASE WESTERN RESERVE UNIV,SCH MED,DEPT PHARMACOL,CLEVELAND,OH 44106
[4]
HIV-2 protease is inactivated after oxidation at the dimer interface and activity can be partly restored with methionine sulphoxide reductase
[J].
Davis, DA
;
Newcomb, FM
;
Moskovitz, J
;
Wingfield, PT
;
Stahl, SJ
;
Kaufman, J
;
Fales, HM
;
Levine, RL
;
Yarchoan, R
.
BIOCHEMICAL JOURNAL,
2000, 346
:305-311

Davis, DA
论文数: 0 引用数: 0
h-index: 0
机构: NCI, HIV & AIDS Malignancy Branch, NIH, Bethesda, MD 20892 USA

Newcomb, FM
论文数: 0 引用数: 0
h-index: 0
机构: NCI, HIV & AIDS Malignancy Branch, NIH, Bethesda, MD 20892 USA

Moskovitz, J
论文数: 0 引用数: 0
h-index: 0
机构: NCI, HIV & AIDS Malignancy Branch, NIH, Bethesda, MD 20892 USA

Wingfield, PT
论文数: 0 引用数: 0
h-index: 0
机构: NCI, HIV & AIDS Malignancy Branch, NIH, Bethesda, MD 20892 USA

Stahl, SJ
论文数: 0 引用数: 0
h-index: 0
机构: NCI, HIV & AIDS Malignancy Branch, NIH, Bethesda, MD 20892 USA

Kaufman, J
论文数: 0 引用数: 0
h-index: 0
机构: NCI, HIV & AIDS Malignancy Branch, NIH, Bethesda, MD 20892 USA

Fales, HM
论文数: 0 引用数: 0
h-index: 0
机构: NCI, HIV & AIDS Malignancy Branch, NIH, Bethesda, MD 20892 USA

Levine, RL
论文数: 0 引用数: 0
h-index: 0
机构: NCI, HIV & AIDS Malignancy Branch, NIH, Bethesda, MD 20892 USA

Yarchoan, R
论文数: 0 引用数: 0
h-index: 0
机构: NCI, HIV & AIDS Malignancy Branch, NIH, Bethesda, MD 20892 USA
[5]
USE OF PROTEIN UNFOLDING STUDIES TO DETERMINE THE CONFORMATIONAL AND DIMERIC STABILITIES OF HIV-1 AND SIV PROTEASES
[J].
GRANT, SK
;
DECKMAN, IC
;
CULP, JS
;
MINNICH, MD
;
BROOKS, IS
;
HENSLEY, P
;
DEBOUCK, C
;
MEEK, TD
.
BIOCHEMISTRY,
1992, 31 (39)
:9491-9501

GRANT, SK
论文数: 0 引用数: 0
h-index: 0
机构: SMITHKLINE BEECHAM PHARMACEUT,DEPT MED CHEM,709 SWEDELAND RD,KING OF PRUSSIA,PA 19406

DECKMAN, IC
论文数: 0 引用数: 0
h-index: 0
机构: SMITHKLINE BEECHAM PHARMACEUT,DEPT MED CHEM,709 SWEDELAND RD,KING OF PRUSSIA,PA 19406

CULP, JS
论文数: 0 引用数: 0
h-index: 0
机构: SMITHKLINE BEECHAM PHARMACEUT,DEPT MED CHEM,709 SWEDELAND RD,KING OF PRUSSIA,PA 19406

MINNICH, MD
论文数: 0 引用数: 0
h-index: 0
机构: SMITHKLINE BEECHAM PHARMACEUT,DEPT MED CHEM,709 SWEDELAND RD,KING OF PRUSSIA,PA 19406

BROOKS, IS
论文数: 0 引用数: 0
h-index: 0
机构: SMITHKLINE BEECHAM PHARMACEUT,DEPT MED CHEM,709 SWEDELAND RD,KING OF PRUSSIA,PA 19406

HENSLEY, P
论文数: 0 引用数: 0
h-index: 0
机构: SMITHKLINE BEECHAM PHARMACEUT,DEPT MED CHEM,709 SWEDELAND RD,KING OF PRUSSIA,PA 19406

DEBOUCK, C
论文数: 0 引用数: 0
h-index: 0
机构: SMITHKLINE BEECHAM PHARMACEUT,DEPT MED CHEM,709 SWEDELAND RD,KING OF PRUSSIA,PA 19406

MEEK, TD
论文数: 0 引用数: 0
h-index: 0
机构: SMITHKLINE BEECHAM PHARMACEUT,DEPT MED CHEM,709 SWEDELAND RD,KING OF PRUSSIA,PA 19406
[6]
Structure of equine infectious anemia virus proteinase complexed with an inhibitor
[J].
Gustchina, A
;
Kervinen, J
;
Powell, DJ
;
Zdanov, A
;
Kay, J
;
Wlodawer, A
.
PROTEIN SCIENCE,
1996, 5 (08)
:1453-1465

Gustchina, A
论文数: 0 引用数: 0
h-index: 0
机构: NCI, ABL BASIC RES PROGRAM, FREDERICK CANC RES & DEV CTR, MACROMOL STRUCT LAB, FREDERICK, MD 21702 USA

Kervinen, J
论文数: 0 引用数: 0
h-index: 0
机构: NCI, ABL BASIC RES PROGRAM, FREDERICK CANC RES & DEV CTR, MACROMOL STRUCT LAB, FREDERICK, MD 21702 USA

Powell, DJ
论文数: 0 引用数: 0
h-index: 0
机构: NCI, ABL BASIC RES PROGRAM, FREDERICK CANC RES & DEV CTR, MACROMOL STRUCT LAB, FREDERICK, MD 21702 USA

Zdanov, A
论文数: 0 引用数: 0
h-index: 0
机构: NCI, ABL BASIC RES PROGRAM, FREDERICK CANC RES & DEV CTR, MACROMOL STRUCT LAB, FREDERICK, MD 21702 USA

Kay, J
论文数: 0 引用数: 0
h-index: 0
机构: NCI, ABL BASIC RES PROGRAM, FREDERICK CANC RES & DEV CTR, MACROMOL STRUCT LAB, FREDERICK, MD 21702 USA

Wlodawer, A
论文数: 0 引用数: 0
h-index: 0
机构: NCI, ABL BASIC RES PROGRAM, FREDERICK CANC RES & DEV CTR, MACROMOL STRUCT LAB, FREDERICK, MD 21702 USA
[7]
THE RETROVIRAL ENZYMES
[J].
KATZ, RA
;
SKALKA, AM
.
ANNUAL REVIEW OF BIOCHEMISTRY,
1994, 63
:133-173

KATZ, RA
论文数: 0 引用数: 0
h-index: 0

SKALKA, AM
论文数: 0 引用数: 0
h-index: 0
[8]
Stabilization from autoproteolysis and kinetic characterization of the human T-cell leukemia virus type 1 proteinase
[J].
Louis, JM
;
Oroszlan, S
;
Tözsér, J
.
JOURNAL OF BIOLOGICAL CHEMISTRY,
1999, 274 (10)
:6660-6666

Louis, JM
论文数: 0 引用数: 0
h-index: 0
机构:
NIDDK, Chem Phys Lab, NIH, Bethesda, MD 20892 USA NIDDK, Chem Phys Lab, NIH, Bethesda, MD 20892 USA

Oroszlan, S
论文数: 0 引用数: 0
h-index: 0
机构: NIDDK, Chem Phys Lab, NIH, Bethesda, MD 20892 USA

Tözsér, J
论文数: 0 引用数: 0
h-index: 0
机构: NIDDK, Chem Phys Lab, NIH, Bethesda, MD 20892 USA
[9]
OVEREXPRESSION OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 PROTEASE INCREASES INTRACELLULAR CLEAVAGE OF GAG AND REDUCES VIRUS INFECTIVITY
[J].
LUUKKONEN, BGM
;
FENYO, EM
;
SCHWARTZ, S
.
VIROLOGY,
1995, 206 (02)
:854-865

LUUKKONEN, BGM
论文数: 0 引用数: 0
h-index: 0
机构:
KAROLINSKA INST, CTR MICROBIOL & TUMORBIOL, S-17177 STOCKHOLM, SWEDEN KAROLINSKA INST, CTR MICROBIOL & TUMORBIOL, S-17177 STOCKHOLM, SWEDEN

FENYO, EM
论文数: 0 引用数: 0
h-index: 0
机构:
KAROLINSKA INST, CTR MICROBIOL & TUMORBIOL, S-17177 STOCKHOLM, SWEDEN KAROLINSKA INST, CTR MICROBIOL & TUMORBIOL, S-17177 STOCKHOLM, SWEDEN

SCHWARTZ, S
论文数: 0 引用数: 0
h-index: 0
机构:
KAROLINSKA INST, CTR MICROBIOL & TUMORBIOL, S-17177 STOCKHOLM, SWEDEN KAROLINSKA INST, CTR MICROBIOL & TUMORBIOL, S-17177 STOCKHOLM, SWEDEN
[10]
THE HIV-1 PROTEASE AS ENZYME AND SUBSTRATE - MUTAGENESIS OF AUTOLYSIS SITES AND GENERATION OF A STABLE MUTANT WITH RETAINED KINETIC-PROPERTIES
[J].
MILDNER, AM
;
ROTHROCK, DJ
;
LEONE, JW
;
BANNOW, CA
;
LULL, JM
;
REARDON, IM
;
SARCICH, JL
;
HOWE, WJ
;
TOMICH, CSC
;
SMITH, CW
;
HEINRIKSON, RL
;
TOMASSELLI, AG
.
BIOCHEMISTRY,
1994, 33 (32)
:9405-9413

MILDNER, AM
论文数: 0 引用数: 0
h-index: 0
机构: UPJOHN CO, UPJOHN LABS, BIOCHEM UNIT, KALAMAZOO, MI 49001 USA

ROTHROCK, DJ
论文数: 0 引用数: 0
h-index: 0
机构: UPJOHN CO, UPJOHN LABS, BIOCHEM UNIT, KALAMAZOO, MI 49001 USA

LEONE, JW
论文数: 0 引用数: 0
h-index: 0
机构: UPJOHN CO, UPJOHN LABS, BIOCHEM UNIT, KALAMAZOO, MI 49001 USA

BANNOW, CA
论文数: 0 引用数: 0
h-index: 0
机构: UPJOHN CO, UPJOHN LABS, BIOCHEM UNIT, KALAMAZOO, MI 49001 USA

LULL, JM
论文数: 0 引用数: 0
h-index: 0
机构: UPJOHN CO, UPJOHN LABS, BIOCHEM UNIT, KALAMAZOO, MI 49001 USA

REARDON, IM
论文数: 0 引用数: 0
h-index: 0
机构: UPJOHN CO, UPJOHN LABS, BIOCHEM UNIT, KALAMAZOO, MI 49001 USA

SARCICH, JL
论文数: 0 引用数: 0
h-index: 0
机构: UPJOHN CO, UPJOHN LABS, BIOCHEM UNIT, KALAMAZOO, MI 49001 USA

HOWE, WJ
论文数: 0 引用数: 0
h-index: 0
机构: UPJOHN CO, UPJOHN LABS, BIOCHEM UNIT, KALAMAZOO, MI 49001 USA

TOMICH, CSC
论文数: 0 引用数: 0
h-index: 0
机构: UPJOHN CO, UPJOHN LABS, BIOCHEM UNIT, KALAMAZOO, MI 49001 USA

SMITH, CW
论文数: 0 引用数: 0
h-index: 0
机构: UPJOHN CO, UPJOHN LABS, BIOCHEM UNIT, KALAMAZOO, MI 49001 USA

HEINRIKSON, RL
论文数: 0 引用数: 0
h-index: 0
机构: UPJOHN CO, UPJOHN LABS, BIOCHEM UNIT, KALAMAZOO, MI 49001 USA

TOMASSELLI, AG
论文数: 0 引用数: 0
h-index: 0
机构: UPJOHN CO, UPJOHN LABS, BIOCHEM UNIT, KALAMAZOO, MI 49001 USA