Metabolically incorporated photocrosslinking sialic acid covalently captures a ganglioside-protein complex

被引：33

作者：

Bond, Michelle R. ^{[1
,2
]}

Whitman, Chad M. ^{[1
,2
]}

Kohler, Jennifer J. ^{[1
]}

机构：

[1] Univ Texas SW Med Ctr Dallas, Dept Internal Med, Div Translat Res, Dallas, TX 75390 USA

[2] Stanford Univ, Dept Chem, Stanford, CA 94305 USA

来源：

MOLECULAR BIOSYSTEMS | 2010年 / 6卷 / 10期

基金：

美国国家卫生研究院;

关键词：

RECOGNIZING PROTEINS; GLYCOSPHINGOLIPIDS; BINDING; CELLS; CONVERSION; INHIBITOR; GM3;

D O I：

10.1039/c0mb00069h

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

When photoirradiated, an unnatural sialic acid analog can covalently capture the complex formed by ganglioside GM1 and cholera toxin subunit B.

引用

页码：1796 / 1799

页数：4

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