Ligand-Promoted C-3 Selective C-H Olefination of Pyridines with Pd Catalysts

被引：294

作者：

Ye, Mengchun ^{[1
]}

Gao, Guo-Lin ^{[1
]}

Yu, Jin-Quan ^{[1
]}

机构：

[1] Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2011年 / 133卷 / 18期

关键词：

NICKEL/LEWIS ACID CATALYSIS; N-IMINOPYRIDINIUM YLIDES; DIRECT ARYLATION; HETEROAROMATIC-COMPOUNDS; BOND ACTIVATION; AROMATIC HETEROCYCLES; PALLADIUM; ALKENYLATION; BORYLATION; DERIVATIVES;

D O I：

10.1021/ja2021075

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Pd-catalyzed C-3 selective olefination of pyridines is developed for the first time using 1,10-phenanthroline as the ligand. This finding provides a novel disconnection for the synthesis of pyridine-containing alkaloids and drug molecules as well as a new approach for developing Pd-catalyzed C H functionalizations of pyridines.

引用

收藏

页码：6964 / 6967

页数：4

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