Dual Ti-Ru Catalysis in the Direct Radical Haloalkylation of N-Acyl Oxazolidinones

被引:65
作者
Gu, Zhenhua [1 ]
Herrmann, Aaron T. [1 ]
Zakarian, Armen [1 ]
机构
[1] Univ Calif Santa Barbara, Dept Chem & Biochem, Santa Barbara, CA 93106 USA
基金
美国国家卫生研究院;
关键词
haloalkylation; homogeneous catalysis; radicals; tautomerism; titanium enolates; VALENCE TAUTOMERISM; RUCL(CP-ASTERISK)(PPH3)(2); AUXILIARY;
D O I
10.1002/anie.201101364
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Waste not, want not: A mechanistic study of the ruthenium-catalyzed haloalkylation of titanium enolates led to the development of a process that is catalytic in both metals: titanium and ruthenium (see scheme; Bn=benzyl, PMP=1,2,2,6,6-pentamethylpiperidine). Catalytic turnover was observed in the formation of the titanium enolates from N-acyl oxazolidinones, and insight was gained into the inhibitory effect of the amine base. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码:7136 / 7139
页数:4
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