Oxygenated cembranoids from a Formosan soft coral Sinulatia gibberosa

被引：36

作者：

Ahmed, Atallah F. ^{[1
,2
]}

Wen, Zhi-Hong ^{[1
]}

Su, Jui-Hsin ^{[1
]}

Hsieh, Ya-Ting ^{[1
]}

Wu, Yang-Chang ^{[3
]}

Hu, Wan-Ping ^{[4
]}

Sheu, Jyh-Horng ^{[1
,5
]}

机构：

[1] Natl Sun Yat Sen Univ, Dept Marine Biotechnol & Resources, Kaohsiung 804, Taiwan

[2] Mansoura Univ, Fac Pharm, Dept Pharmacognosy, Mansoura, Egypt

[3] Kaohsiung Med Univ, Grad Inst Nat Prod, Kaohsiung 807, Taiwan

[4] Kaohsiung Med Univ, Fac Biotechnol, Kaohsiung 807, Taiwan

[5] Natl Sun Yat Sen Univ, Asia Pacific Ocean Res Ctr, Kaohsiung 804, Taiwan

来源：

JOURNAL OF NATURAL PRODUCTS | 2008年 / 71卷 / 02期

关键词：

D O I：

10.1021/np070356p

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Chemical investigation of a Formosan soft coral, Sinularia gibberosa, has led to the isolation of eight oxygenated cembranoids, 1-8, including seven new compounds, gibberosenes A-G (2-8). None of these compounds were found to be cytotoxic toward a limited panel of cancer cell lines. Compound 1 significantly inhibited the accumulation of the pro-inflammatory COX-2 protein of the LPS-stimulated RAW264.7 macrophage cells.

引用

页码：179 / 185

页数：7

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