Selective, orally active MMP inhibitors with an aryl backbone

被引：21

作者：

Barta, TE

Becker, DP

Bedell, LJ

De Crescenzo, GA

McDonald, JJ

Mehta, P

Munie, GE

Villamil, CI

机构：

[1] Pharmacia, Dept Med Chem, Skokie, IL 60077 USA

[2] Pharmacia, Dept Med Chem, St Louis, MO 63198 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2001年 / 11卷 / 18期

关键词：

D O I：

10.1016/S0960-894X(01)00487-5

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

This letter describes SAR exploration and rat PK optimization of a series of novel, MMP-1 sparing aryl hydroxamate sulfonamides with activity against MMP-2 and MMP-13. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：2481 / 2483

页数：3

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