Epigenetic control: slow and global, nimble and local

被引：6

作者：

Cheng, Christine S. ^{[2
]}

Johnson, Tracy L. ^{[1
]}

Hoffmann, Alexander ^{[2
]}

机构：

[1] Univ Calif San Diego, Div Biol, La Jolla, CA 92093 USA

[2] Univ Calif San Diego, Dept Chem & Biochem, Signalling Syst Lab, La Jolla, CA 92093 USA

来源：

GENES & DEVELOPMENT | 2008年 / 22卷 / 09期

关键词：

epigenetics; inflammation; NF-kappa B; gene expression; phosphorylation;

D O I：

10.1101/gad.1677008

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The regulation of gene expression involves multiple levels of control, from those that are inheritable to those that are highly responsive to environmental changes. In this issue of Genes & Development, Dong and colleagues (pp. 1159 - 1173) demonstrate that the dynamically controlled immune response transcription factor NF-kappa B may, in fact, have a role in regulating heterochromatin and gene expression at large distances from its actual target sequences and genes.

引用

页码：1110 / 1114

页数：5

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